N-HYDROXYSUCCINIMIDYL CHLOROFORMATE

Base Information

• Chemical Name: N-HYDROXYSUCCINIMIDYL CHLOROFORMATE
• CAS No.: 15149-73-2
• Molecular Formula: C5H4 Cl N O4
• Molecular Weight: 177.544
• Hs Code.: 2925190090
• Mol file: 15149-73-2.mol

Synonyms:2,5-Pyrrolidinedione,1-[(chlorocarbonyl)oxy]- (9CI); Succinimide, N-[(chloroformyl)oxy]- (8CI);N-Hydroxysuccinimide chloroformate; Succinimido chloroformate; Succinimidylchloroformate

Chemical Property of N-HYDROXYSUCCINIMIDYL CHLOROFORMATE

Chemical Property:

• PSA: 63.68000
• LogP: 0.36370

Purity/Quality:

98% ^*data from raw suppliers

N-HYDROXYSUCCINIMIDYL CHLOROFORMATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-HYDROXYSUCCINIMIDYL CHLOROFORMATE

There total 3 articles about N-HYDROXYSUCCINIMIDYL CHLOROFORMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + trichloromethyl chloroformate (503-38-8) → 2,5-dioxopyrrolidin-1-yl carbonochloridate (15149-73-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; 1.) 0 deg C, 0.5 h, 2.) reflux, 2 h;

DOI:10.1055/s-1993-25809

Reference yield: 80.0%

phosgene (75-44-5) + dicyclohexylamine salt of N-hydroxysuccinimide (82911-72-6) → 2,5-dioxopyrrolidin-1-yl carbonochloridate (15149-73-2)

Guidance literature:

In dichloromethane; at -5 ℃; for 4h;

DOI:10.1139/v82-146

Reference yield:

→ 2,5-dioxopyrrolidin-1-yl carbonochloridate (15149-73-2)

Guidance literature:

N-Hydroxy-succinimid-K, Phosgen, CH2Cl2, -5grad;

upstream raw materials:

phosgene

dicyclohexylamine salt of N-hydroxysuccinimide

1-hydroxy-pyrrolidine-2,5-dione

trichloromethyl chloroformate

Downstream raw materials:

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

2,5-dioxopyrrolidin-1-yl methylcarbamate

1,2,2,2-tetrachloroethyl-(N-succinimidyl)carbonate

Refernces

• 1、 Konakahara,Ozaki,Sato,Gold. "A convenient method for the synthesis of activated N-methylcarbamates". . p. 103 - 106. Retrieved 2007/10/02.