2,4,5-Trimethoxytoluene

Base Information

• Chemical Name: 2,4,5-Trimethoxytoluene
• CAS No.: 14894-74-7
• Molecular Formula: C10H14 O3
• Molecular Weight: 182.219
• DSSTox Substance ID: DTXSID50505510
• Nikkaji Number: J534.830G
• Wikidata: Q27155293
• Mol file: 14894-74-7.mol

Synonyms:2,4,5-Trimethoxytoluene;14894-74-7;2,4,5-Trimethoxy toluene;1,2,4-TRIMETHOXY-5-METHYLBENZENE;SCHEMBL3677762;CHEBI:81355;DTXSID50505510;AKOS006293934;AB20919;AC-12730;FT-0691408;C17823;Q27155293

Chemical Property of 2,4,5-Trimethoxytoluene

Chemical Property:

• Vapor Pressure: 0.021mmHg at 25°C
• Melting Point: 55 °C
• Refractive Index: 1.487
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 27.69000
• Density: 1.025g/cm³
• LogP: 2.02080
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 182.094294304
• Heavy Atom Count: 13
• Complexity: 149

Purity/Quality:

98%Min ^*data from raw suppliers

2,4,5-TRIMETHOXY TOLUENE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1OC)OC)OC

Technology Process of 2,4,5-Trimethoxytoluene

There total 16 articles about 2,4,5-Trimethoxytoluene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

asaraldehyde (4460-86-0,14374-62-0) → 1,2,4-trimethoxy-5-methylbenzene (14894-74-7)

Guidance literature:

With triethylsilane; chloro-trimethyl-silane; In acetonitrile;

DOI:10.1016/j.tetlet.2018.01.007

Reference yield: 78.0%

1,2,5-trimethoxy-3-(propylthio)-4-methylbenzene (138865-91-5) → 1,2,4-trimethoxy-5-methylbenzene (14894-74-7)

Guidance literature:

NiRa; In ethanol; for 2h; Heating;

DOI:10.1016/S0040-4020(01)96216-7

Reference yield: 78.0%

1,2,4-trimethoxy-3-trimethylsilyl-5-methylbenzene (138865-90-4) → 1,2,4-trimethoxy-5-methylbenzene (14894-74-7)

Guidance literature:

With cesium fluoride; In water; N,N-dimethyl-formamide; for 24h; Heating;

DOI:10.1016/S0040-4020(01)96216-7

upstream raw materials:

2,5-dihydroxy-4-methoxytoluene

dimethyl sulfate

1,2,5-trimethoxy-3-(propylthio)-4-methylbenzene

1,2,4-trimethoxy-3-trimethylsilyl-5-methylbenzene

Downstream raw materials:

asaronic acid

1,2,4-trimethoxy-3-trimethylsilyl-5-methylbenzene

asaraldehyde

C₁₄H₁₃NO₂

Refernces

• 1、 McDonald, Jeffrey W.,Miller, John E.,Kim, Minjee,Velu, Sadanandan E.. "An expedient synthesis of murrayaquinone A via a novel oxidative free radical reaction". . p. 550 - 553. Retrieved 2018/01/17.
• 2、 Chattopadhyay, Sarmishtha,Banerjee, Sajal Kumar,Mitra, Alok Kumar. "The Huang-Minlon modification of Wolff-Kishner reduction in rapid and simple way using microwave technology". . p. 906 - 907. Retrieved 2007/10/03.