4-(N-METHYLAMINO)-3-NITRO PHENOL

Base Information

• Chemical Name: 4-(N-METHYLAMINO)-3-NITRO PHENOL
• CAS No.: 14703-88-9
• Molecular Formula: C7H8N2O3
• Molecular Weight: 168.152
• Hs Code.: 2922299090
• Mol file: 14703-88-9.mol

Synonyms:2-Nitro-4-hydroxy-N-methylaniline;4-(Methylamino)-3-nitrophenol;4-(N-Methylamino)-3-nitro phenol;

Chemical Property of 4-(N-METHYLAMINO)-3-NITRO PHENOL

Chemical Property:

• Vapor Pressure: 2.38E-05mmHg at 25°C
• Refractive Index: 1.665
• Boiling Point: 349.2 °C at 760 mmHg
• Flash Point: 165 °C
• PSA: 78.08000
• Density: 1.411 g/cm³
• LogP: 1.93830

Purity/Quality:

98%min ^*data from raw suppliers

4-(N-Methylamino)-3-nitrophenol 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(N-METHYLAMINO)-3-NITRO PHENOL

There total 4 articles about 4-(N-METHYLAMINO)-3-NITRO PHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

4-(4-methoxybenzyl)oxy-N-methyl-2-nitroaniline → 4-(methylamino)-3-nitrophenol (14703-88-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 6h;

Reference yield: 54.0%

4-fluoro-3-nitrophenol (2105-96-6) + methylamine (74-89-5) → 4-(methylamino)-3-nitrophenol (14703-88-9)

Guidance literature:

In 1-methyl-pyrrolidin-2-one; at 50 ℃; for 20h;

Reference yield:

4-(4-methoxybenzyloxy)-2-nitrobenzenamine (1414615-60-3) → 4-(methylamino)-3-nitrophenol (14703-88-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide / 2.5 h / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

With sodium hydride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

4-(4-methoxybenzyloxy)-2-nitrobenzenamine

4-hydroxy-2-nitroaniline

4-fluoro-3-nitrophenol

methylamine

Downstream raw materials:

N-(4-(4-(methylamino)-3-nitrophenoxy)pyridin-2-yl)acetamide

4-(4-Methylamino-3-nitro-phenoxy)-pyridine-2-carbonitrile

2-nitro 4-hydroxy N-methyl N-carbethoxy acetyl aniline

3-amino-4-methylaminophenol

Refernces

• 1、 -. "Benzimidazole compound, and preparation method, intermediate and application thereof". . . Retrieved 2016/10/20.