spiro[adamantane-2,4'-imidazolidine]-2',5'-dione

Base Information

• Chemical Name: spiro[adamantane-2,4'-imidazolidine]-2',5'-dione
• CAS No.: 50346-47-9
• Molecular Formula: C₁₂H₁₆N₂O₂
• Molecular Weight: 220.271
• Mol file: 50346-47-9.mol

Synonyms:spiro[adamantane-2,4'-imidazolidine]-2',5'-dione

Chemical Property of spiro[adamantane-2,4'-imidazolidine]-2',5'-dione

Chemical Property:

Purity/Quality:

99%min ^*data from raw suppliers

PHERO26237 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of spiro[adamantane-2,4'-imidazolidine]-2',5'-dione

There total 4 articles about spiro[adamantane-2,4'-imidazolidine]-2',5'-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

sodium cyanide (773837-37-9) + 2-Adamantanone (700-58-3) + ammonium carbonate (506-87-6,6721-33-1,10361-29-2) → spiro[adamantane-2,4'-imidazolidine]-2',5'-dione (50346-47-9)

Guidance literature:

In ethanol; water; at 150 ℃; for 2h;

DOI:10.1021/op300084z

Reference yield: 11.0%

sodium cyanide (773837-37-9) + 2-Adamantanone (700-58-3) → spiro[adamantane-2,4'-imidazolidine]-2',5'-dione (50346-47-9)

Guidance literature:

With ammonium carbonate; In ethanol; water; at 20 - 150 ℃; for 2h; Inert atmosphere; Microwave irradiation;

DOI:10.1016/j.bmc.2013.04.075

Reference yield:

2-Adamantanone (700-58-3) → spiro[adamantane-2,4'-imidazolidine]-2',5'-dione (50346-47-9)

Guidance literature:

With ammonium carbonate; In water ethanol;

upstream raw materials:

2-Adamantanone

sodium cyanide

ammonium carbonate

Downstream raw materials:

2-amino-2-adamantanecarboxylic acid

Refernces

• 1、 Battilocchio, Claudio,Baxendale, Ian R.,Biava, Mariangela,Kitching, Matthew O.,Ley, Steven V.. "A flow-based synthesis of 2-aminoadamantane-2-carboxylic acid". supporting information; experimental part. p. 798 - 810. Retrieved 2012/08/27.
• 2、 Nagasawa et al.. "2-Aminoadamantane-2-carboxylic acid, a rigid, achiral, tricyclic alpha-amino acid with transport inhibitory properties.". . p. 823,826. Retrieved 2007/10/06.