4-(TRIFLUOROMETHOXY)PHENYLHYDRAZINE HYDROCHLORIDE

Base Information

• Chemical Name: 4-(TRIFLUOROMETHOXY)PHENYLHYDRAZINE HYDROCHLORIDE
• CAS No.: 13957-54-5
• Molecular Formula: C7H7 F3 N2 O
• Molecular Weight: 192.141
• Hs Code.: 2928000090
• Mol file: 13957-54-5.mol

Synonyms:Hydrazine,[p-(trifluoromethoxy)phenyl]- (8CI);4-Trifluoromethoxyphenylhydrazine;N-[4-(Trifluoromethoxy)phenyl]hydrazine;

Chemical Property of 4-(TRIFLUOROMETHOXY)PHENYLHYDRAZINE HYDROCHLORIDE

Chemical Property:

• Melting Point: 230 °C(lit.)
• Boiling Point: 228.9±40.0 °C(Predicted)
• PKA: 4.91±0.20(Predicted)
• PSA: 47.28000
• Density: 1.408±0.06 g/cm3(Predicted)
• LogP: 2.64410
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

[4-(Trifluoromethoxy)phenyl]hydrazine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(TRIFLUOROMETHOXY)PHENYLHYDRAZINE HYDROCHLORIDE

There total 5 articles about 4-(TRIFLUOROMETHOXY)PHENYLHYDRAZINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

→ [4-(trifluoromethoxy)phenyl]hydrazine (13957-54-5)

Guidance literature:

Reference yield: 15.6%

4-(trifluoromethoxy)aniline (461-82-5) → [4-(trifluoromethoxy)phenyl]hydrazine (13957-54-5)

Guidance literature:

4-(trifluoromethoxy)aniline; With hydrogenchloride; NaNO₂; In water monomer; for 0.5h; Cooling with ice;

With hydrogenchloride; stannous chloride monohydrate; In water monomer; at 0 ℃; for 2h;

Reference yield:

1-chloro-4-(trifluoromethoxy)benzene (461-81-4) → [4-(trifluoromethoxy)phenyl]hydrazine (13957-54-5)

Guidance literature:

With chloro[2-(dicyclohexylphosphino)-3 ,6-dimethoxy-2’,4’, 6’-triisopropyl- 1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II); sodium t-butanolate; hydrazine; In tetrahydrofuran; at 20 ℃; for 0.1h; Flow reactor; Sonication; Inert atmosphere;

DOI:10.1002/anie.201208544

upstream raw materials:

di-tert-butyl 1-(4-(trifluoromethoxy)phenyl)hydrazine-1,2-dicarboxylate

1-chloro-4-(trifluoromethoxy)benzene

4-(trifluoromethoxy)aniline

Downstream raw materials:

1-(4-trifluoromethoxy-phenyl)-1,4,5,6-tetrahydro-1,2,6,7-tetraaza-as-indacene-3-carboxylic acid ethyl ester

5-Dodecyloxy-3-(4-trifluoromethoxy-phenyl)-3H-(1,3,4)-oxadiazol-2-one

3-[5-(4-Benzyloxy-phenyl)-1-(4-trifluoromethoxy-phenyl)-1H-pyrazol-3-yl]-2-m-tolyl-propionic acid

2-{[4-(trifluoromethoxy)phenyl]hydrazono}propanedial dioxime

Refernces

• 1、 -. "ASYMMETRIC TRIAZOLE BENZAMIDE DERIVATIVES AND THE COMPOSITIONS AND METHODS OF TREATMENT REGARDING THE SAME". Paragraph 706. . Retrieved 2019/06/17.
• 2、 Deangelis, Andrew,Wang, Dong-Hui,Buchwald, Stephen L.. "Mild and rapid Pd-catalyzed cross-coupling with hydrazine in continuous flow: Application to the synthesis of functionalized heterocycles". supporting information. p. 3434 - 3437. Retrieved 2013/05/09.