p-formylbenzonitrile neopentyl glycol acetal

Base Information

• Chemical Name: p-formylbenzonitrile neopentyl glycol acetal
• CAS No.: 106456-92-2
• Molecular Formula: C₁₃H₁₅NO₂
• Molecular Weight: 217.268
• Mol file: 106456-92-2.mol

Synonyms:p-formylbenzonitrile neopentyl glycol acetal

Chemical Property of p-formylbenzonitrile neopentyl glycol acetal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of p-formylbenzonitrile neopentyl glycol acetal

There total 4 articles about p-formylbenzonitrile neopentyl glycol acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,2-Dimethyl-1,3-propanediol (126-30-7) + 4-cyanobenzaldehyde (105-07-7) → p-formylbenzonitrile neopentyl glycol acetal (106456-92-2)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 1.5h; Heating;

DOI:10.1246/bcsj.64.3005

Reference yield: 95.0%

4-cyanobenzoic acid methyl ester (1129-35-7) + 5,5-dimethyl-2-(4-methylsulfanylphenyl)-1,3-dioxane (251989-43-2) → p-formylbenzonitrile neopentyl glycol acetal (106456-92-2)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; 1,2-bis-(dicyclohexylphosphino)ethane; In o-xylene; at 140 ℃; for 24h; Glovebox; Inert atmosphere;

DOI:10.1021/jacs.1c00529

Reference yield: 89.0%

zinc(II) cyanide (557-21-1) + 5,5-dimethyl-2-(4-methylsulfanylphenyl)-1,3-dioxane (251989-43-2) → p-formylbenzonitrile neopentyl glycol acetal (106456-92-2)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; potassium acetate; 1,2-bis-(dicyclohexylphosphino)ethane; In 1,4-dioxane; at 110 ℃; for 16h; Glovebox;

DOI:10.1021/acs.orglett.1c02285

upstream raw materials:

2,2-Dimethyl-1,3-propanediol

4-cyanobenzaldehyde

2-(4-chlorophenyl)-5,5-dimethyl-1,3-dioxane

2-methyl-2-phenylmalononitrile

Downstream raw materials:

methyl 3-(4-(5,5-dimethyl-1,3-dioxan-2-yl)phenyl)-5-methyl-1-phenyl-1H-pyrazole-4-carboxylate

2-Hexyl-6-[4-((1Z,4Z,9Z,15Z)-2,8,12,18-tetrahexyl-3,7,13,17-tetramethyl-15-p-tolyl-porphyrin-5-yl)-benzyl]-pyrrolo[3,4-f]isoindole-1,3,5,7-tetraone

N-hexyl-N'<(4-formylphenyl)methyl>1,2:4,5-benzenebis(dicarboximide)

4-(5,5-dimethyl-1,3-dioxan-2-yl)benzylamine

Refernces

• 1、 Delcaillau, Tristan,Woenckhaus-Alvarez, Adrian,Morandi, Bill. "Nickel-Catalyzed Cyanation of Aryl Thioethers". supporting information. p. 7018 - 7022. Retrieved 2021/09/13.
• 2、 Yi, Fengping,Gao, Jie,Zhang, Lirong,Jiang, Xiaoyan. "New Br?nsted-Lewis acidic quaternary ammonium ionic liquids: Synthesis, acidity determination and acidity-catalytic activity relationship". . p. 1260 - 1264. Retrieved 2015/02/19.