2-ISOPROPYL-4-HYDROXY ANISOLE

Base Information

• Chemical Name: 2-ISOPROPYL-4-HYDROXY ANISOLE
• CAS No.: 13523-62-1
• Molecular Formula: C10H14 O2
• Molecular Weight: 166.22
• Hs Code.: 2909500000
• Mol file: 13523-62-1.mol

Synonyms:Phenol,3-isopropyl-4-methoxy- (6CI,7CI,8CI); 3-Isopropyl-4-methoxyphenol

Chemical Property of 2-ISOPROPYL-4-HYDROXY ANISOLE

Chemical Property:

• Vapor Pressure: 0.00232mmHg at 25°C
• Refractive Index: 1.517
• Boiling Point: 279.8°Cat760mmHg
• PKA: 10.52±0.18(Predicted)
• Flash Point: 134.6°C
• PSA: 29.46000
• Density: 1.026g/cm³
• LogP: 2.52420

Purity/Quality:

98%min ^*data from raw suppliers

2-Isopropyl-4-hydroxyanisole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-ISOPROPYL-4-HYDROXY ANISOLE

There total 6 articles about 2-ISOPROPYL-4-HYDROXY ANISOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3‐isopropyl‐4‐methoxybenzaldehyde (31825-29-3) → 3-iso-propyl-4-methoxyphenol (13523-62-1)

Guidance literature:

With sulfuric acid; dihydrogen peroxide; In methanol;

DOI:10.1016/j.bmcl.2021.127778

Reference yield: 86.0%

4-isopropyl-4-methoxy-2,5-cyclohexadienone (110391-95-2) → 3-iso-propyl-4-methoxyphenol (13523-62-1)

Guidance literature:

With rhenium(VII) oxide; In dichloromethane; at 20 ℃;

DOI:10.1039/c5ra04931h

Reference yield: 79.0%

o-isopropylanisole (2944-47-0) → 3-iso-propyl-4-methoxyphenol (13523-62-1)

Guidance literature:

With dirhodium tetraacetate; [bis(acetoxy)iodo]benzene; trifluoroacetic anhydride; at 80 ℃; for 1.5h;

upstream raw materials:

3-Isopropyl-4-methoxy-phenylamine; hydrochloride

3‐isopropyl‐4‐methoxybenzaldehyde

4-isopropyl-4-methoxy-2,5-cyclohexadienone

o-isopropylanisole

Downstream raw materials:

DL-N-Acetyl-3-<3,5-dinitro-4-(4-methoxy-3-isopropyl-phenoxy)-phenyl>-2-amino-propionsaeure-ethylester

L-N-Acetyl-3-<3,5-dinitro-4-(4-methoxy-3-isopropyl-phenoxy)-phenyl>-2-amino-propionsaeure-ethylester

C₁₆H₁₃Cl₄NO₄

4-(2,6-dibromo-3-methyl-4-nitrophenoxy)-2-isopropylanisole

Refernces

• 1、 -. "Synthetic method 4 - alkoxyphenol compounds". Paragraph 0079-0081. . Retrieved 2021/09/29.
• 2、 Kitamura, Seiya,Hvorecny, Kelli L.,Niu, Jun,Hammock, Bruce D.,Madden, Dean R.,Morisseau, Christophe. "Rational Design of Potent and Selective Inhibitors of an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa". . p. 4790 - 4799. Retrieved 2016/06/13.