5,6-cis-1α-Hydroxyvitamin D₂ 3-acetate

Base Information

• Chemical Name: 5,6-cis-1α-Hydroxyvitamin D₂ 3-acetate
• CAS No.: 73809-45-7
• Molecular Formula: C₃₀H₄₆O₃
• Molecular Weight: 454.693
• Mol file: 73809-45-7.mol

Synonyms:5,6-cis-1α-Hydroxyvitamin D₂ 3-acetate

Chemical Property of 5,6-cis-1α-Hydroxyvitamin D₂ 3-acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,6-cis-1α-Hydroxyvitamin D₂ 3-acetate

There total 4 articles about 5,6-cis-1α-Hydroxyvitamin D₂ 3-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

1α-Hydroxy-3,5-cyclovitamin D2 (67657-85-6) + acetic acid (64-19-7,77671-22-8) → 5,6-cis-1α-Hydroxyvitamin D2 3-acetate (73809-45-7) + 5,6-trans-1α-Hydroxyvitamin D2 3-acetate (73809-46-8)

Guidance literature:

at 55 ℃; for 15h;

DOI:10.1021/jo01304a022

Reference yield:

3,5-Cyclovitamin D2 (74035-72-6) → 5,6-cis-1α-Hydroxyvitamin D2 3-acetate (73809-45-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 mg / t-BuOOH, SeO₂ / CH₂Cl₂ / 0.83 h / Ambient temperature

2: 48 percent / 15 h / 55 °C

With tert.-butylhydroperoxide; selenium(IV) oxide; In dichloromethane;

DOI:10.1021/jo01304a022

Reference yield:

Vitamin D2 tosylate (72204-99-0) → 5,6-cis-1α-Hydroxyvitamin D2 3-acetate (73809-45-7)

Guidance literature:

Multi-step reaction with 3 steps

1: NaHCO₃ / 8 h / 55 °C

2: 40 mg / t-BuOOH, SeO₂ / CH₂Cl₂ / 0.83 h / Ambient temperature

3: 48 percent / 15 h / 55 °C

With tert.-butylhydroperoxide; selenium(IV) oxide; sodium hydrogencarbonate; In dichloromethane;

DOI:10.1021/jo01304a022

upstream raw materials:

1α-Hydroxy-3,5-cyclovitamin D₂

acetic acid

3,5-Cyclovitamin D₂

Vitamin D₂ tosylate

Downstream raw materials:

1α-Hydroxyvitamin D₂

Refernces