2-CHLOROINOSINE

Base Information

• Chemical Name: 2-CHLOROINOSINE
• CAS No.: 13276-43-2
• Molecular Formula: C10H11ClN4O5
• Molecular Weight: 302.674
• Mol file: 13276-43-2.mol

Synonyms:2-Chloroinosine;8-chloro-9-[(2R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-purin-6-one;

Chemical Property of 2-CHLOROINOSINE

Chemical Property:

• Appearance/Colour: Off-White to Tan Solid
• Melting Point: 141-143°C (dec.)
• PSA: 133.49000
• Density: 2.194 g/cm³
• LogP: -1.61550
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly, Sonicated)

Purity/Quality:

98%, ^*data from raw suppliers

2-Chloroinosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Halogenated nucleoside.

Technology Process of 2-CHLOROINOSINE

There total 5 articles about 2-CHLOROINOSINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

G (118-00-3) → 5-amino-3-β-D-ribofuranosyl-3H-imidaso<4,5-d><1,3>oxazin-7-one (80394-72-5) + 2-chloroinosine (13276-43-2) + xanthosine (146-80-5)

Guidance literature:

With sodium acetate; sodium chloride; sodium nitrite; In water; at 37 ℃; for 2h; pH=3.2; Product distribution;

DOI:10.1016/S0968-0896(01)00173-0

Reference yield:

C10H11N6O6(1-) → 5-amino-3-β-D-ribofuranosyl-3H-imidaso<4,5-d><1,3>oxazin-7-one (80394-72-5) + 2-chloroinosine (13276-43-2) + xanthosine (146-80-5)

Guidance literature:

With phosphate buffer; sodium chloride; In water; at 37 ℃; for 1h; pH=7.4; Product distribution;

DOI:10.1016/S0968-0896(01)00173-0

Reference yield:

2-Chloroadenosine (146-77-0) → 2-chloroinosine (13276-43-2)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; at 4 ℃; for 3h;

DOI:10.1021/tx980160c

upstream raw materials:

2-Chloroadenosine

2-Chlor-inosin-5'-phosphat

G

Refernces

• 1、 Sodum, Rama S.,Fiala, Emerich S.. "N2-amination of guanine to 2-hydrazinohypoxanthine, a novel in vivo nucleic acid modification produced by the hepatocarcinogen 2-nitropropane". . p. 1453 - 1459. Retrieved 2007/10/03.