norethisterone phenylacetate

Base Information

• Chemical Name: norethisterone phenylacetate
• CAS No.: 89094-63-3
• Molecular Formula: C₂₈H₃₂O₃
• Molecular Weight: 416.56
• Mol file: 89094-63-3.mol

Synonyms:norethisterone phenylacetate

Chemical Property of norethisterone phenylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of norethisterone phenylacetate

There total 3 articles about norethisterone phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

phenylacetic acid (103-82-2) + norethisterone (68-22-4) → norethisterone phenylacetate (89094-63-3)

Guidance literature:

With sodium carbonate; trifluoroacetic anhydride; In benzene; for 2.25h; Ambient temperature;

DOI:10.1016/0039-128X(85)90027-3

Reference yield:

norethisterone (68-22-4) + phenylacetyl chloride (103-80-0) → norethisterone phenylacetate (89094-63-3)

Guidance literature:

With thallium (I) ethoxide; In benzene; at 0 - 5 ℃; Yield given;

DOI:10.1016/0039-128X(83)90101-0

Reference yield:

phenylacetic acid (103-82-2) → norethisterone phenylacetate (89094-63-3)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / benzene / Heating

2: TlOEt / benzene / 0 - 5 °C

With thionyl chloride; thallium (I) ethoxide; In benzene;

DOI:10.1016/0039-128X(83)90101-0

upstream raw materials:

phenylacetic acid

norethisterone

phenylacetyl chloride

Refernces

• 1、 Wan, A. S. C.,Ngiam, T. L.,Leung, S. L.,Go, M. L.,Heng, P. W. S.,et al.. "LONG-ACTING CONTRACEPTIVE AGENTS: NORETHISTERONE ESTERS OF ARYLCARBOXYLIC ACIDS". . p. 309 - 320. Retrieved 2007/10/02.