2-BROMO-2-METHYL-PROPIONALDEHYDE

Base Information

• Chemical Name: 2-BROMO-2-METHYL-PROPIONALDEHYDE
• CAS No.: 13206-46-7
• Molecular Formula: C4H7 Br O
• Molecular Weight: 151.003
• Hs Code.: 2913000090
• Mol file: 13206-46-7.mol

Synonyms:Propionaldehyde,2-bromo-2-methyl- (6CI,7CI,8CI); 2-Bromo-2-methylpropanal;2-Bromo-2-methylpropionaldehyde; 2-Bromoisobutyraldehyde; a-Bromoisobutyraldehyde

Chemical Property of 2-BROMO-2-METHYL-PROPIONALDEHYDE

Chemical Property:

• Melting Point: 111-112 °C
• Refractive Index: 1.4518
• Boiling Point: 113°C (rough estimate)
• PSA: 17.07000
• Density: 1.3830
• LogP: 1.35880

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromo-2-methylpropanal ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Bromo-2-methylpropanal is useful in the synthesis of quinazolinones, benzoxazinones, and benzothiazinones

Technology Process of 2-BROMO-2-METHYL-PROPIONALDEHYDE

There total 22 articles about 2-BROMO-2-METHYL-PROPIONALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

(C4H9)3SnOC(CH3)2CHBr2 (39767-67-4) → 2-bromo-2-methylpropanal (13206-46-7) + tributyltin bromide (1461-23-0)

Guidance literature:

decompn. at 170°C (0.5 h);

Reference yield: 70.0%

isobutyraldehyde (78-84-2) → 2-bromo-2-methylpropanal (13206-46-7)

Guidance literature:

With 5,5-dibromobarbituric acid; In diethyl ether; for 10h; Ambient temperature;

Reference yield: 61.0%

2-nitro-3,3-dimethyloxirane (39583-31-8) → 2-bromo-2-methylpropanal (13206-46-7)

Guidance literature:

With magnesium bromide; In diethyl ether; at -10 ℃; for 0.5h;

upstream raw materials:

isobutyraldehyde diethyl acetal

α-bromo-isobutyraldehyde dimethylacetal

2-bromo-1,1-diethoxy-2-methyl-propane

isobutyraldehyde

Downstream raw materials:

2,5-dihydro-5,5-dimethyl-2-(1-methylethyl)-thiazole

2-(4-Methoxy-2-nitro-phenoxy)-2-methyl-propionaldehyde

2-(4-chloro-2-cyanophenoxy)-2-methylpropanal

α-ethoxy-isobutyraldehyde-(2,4-dinitro-phenylhydrazone)

Refernces

• 1、 -. "IMMUNOPROTEASOME INHIBITORS". Paragraph 0213. . Retrieved 2018/08/20.
• 2、 -. "SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF". Paragraph 0250; 0251. . Retrieved 2014/09/30.