(4-Chlorobenzyl)pyridin-3-ylamine dihydrochloride

Base Information

• Chemical Name: (4-Chlorobenzyl)pyridin-3-ylamine dihydrochloride
• CAS No.: 13159-78-9
• Molecular Formula: C12H11 Cl N2
• Molecular Weight: 291.60402
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID00697671
• Mol file: 13159-78-9.mol

Synonyms:13159-78-9;(4-chlorobenzyl)pyridin-3-ylamine dihydrochloride;N-(4-Chlorobenzyl)pyridin-3-amine dihydrochloride;N-[(4-chlorophenyl)methyl]pyridin-3-amine;dihydrochloride;(4-CHLORO-BENZYL)-PYRIDIN-3-YL-AMINE DIHYDROCHLORIDE;starbld0017829;DTXSID00697671;SB82442;(4-chlorobenzyl)pyridin-3-ylamine 2HCl;N-[(4-CHLOROPHENYL)METHYL]PYRIDIN-3-AMINE DIHYDROCHLORIDE;N-[(4-Chlorophenyl)methyl]pyridin-3-amine--hydrogen chloride (1/2)

Chemical Property of (4-Chlorobenzyl)pyridin-3-ylamine dihydrochloride

Chemical Property:

• PSA: 24.92000
• LogP: 5.02410
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 290.014432
• Heavy Atom Count: 17
• Complexity: 179

Purity/Quality:

99% ^*data from raw suppliers

(4-CHLORO-BENZYL)-PYRIDIN-3-YL-AMINE DIHYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CN=C1)NCC2=CC=C(C=C2)Cl.Cl.Cl

Technology Process of (4-Chlorobenzyl)pyridin-3-ylamine dihydrochloride

There total 5 articles about (4-Chlorobenzyl)pyridin-3-ylamine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

pyridin-3-ylamine (462-08-8) + para-Chlorobenzyl alcohol (873-76-7) → N-(pyridin-3-yl)-[(4-chlorophenyl)methyl]amine (13159-78-9)

Guidance literature:

With benzaldehyde; sodium hydroxide; at 150 ℃; for 24h; Schlenk technique; Green chemistry;

DOI:10.1002/adsc.201200881

Reference yield: 43.0%

[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-pyridin-3-yl-amine → N-(pyridin-3-yl)-[(4-chlorophenyl)methyl]amine (13159-78-9)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 4h; Heating;

Reference yield:

N-[(4-chlorophenyl)methyl]-(3-pyridyl)imine → N-(pyridin-3-yl)-[(4-chlorophenyl)methyl]amine (13159-78-9)

Guidance literature:

With sodium borohydrid; In methanol; water;

upstream raw materials:

pyridin-3-ylamine

4-chlorobenzaldehyde

para-Chlorobenzyl alcohol

Refernces

• 1、 Fioravanti,Biava,Donnarumma,Porretta,Simonetti,Villa,Porta-Puglia,Deidda,Maullu,Pompei. "Synthesis and microbiological evaluations of (N-heteroaryl)arylmethanamines and their Schiff bases". . p. 643 - 652. Retrieved 2007/10/03.