Z-MET-GLY-OH

Base Information

• Chemical Name: Z-MET-GLY-OH
• CAS No.: 13139-55-4
• Molecular Formula: C15H20 N2 O5 S
• Molecular Weight: 340.4
• Hs Code.: 2930909090
• Mol file: 13139-55-4.mol

Synonyms:Glycine,N-(N-carboxy-L-methionyl)-, N-benzyl ester (6CI,7CI,8CI)

Chemical Property of Z-MET-GLY-OH

Chemical Property:

• Vapor Pressure: 1.35E-17mmHg at 25°C
• Refractive Index: 1.568
• Boiling Point: 646.5°C at 760 mmHg
• Flash Point: 344.8°C
• PSA: 130.03000
• Density: 1.284g/cm³
• LogP: 2.01710
• Storage Temp.: -15°C

Purity/Quality:

99%+, ^*data from raw suppliers

Z-L-METHIONYL GLYCINE 99.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-MET-GLY-OH

There total 8 articles about Z-MET-GLY-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Z-Met-Gly-OtBu (144889-36-1) → Z-Met-Gly-OH (13139-55-4)

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1016/S0040-4039(00)79116-7

Reference yield:

Cbz-Met-OH (1152-62-1) → Z-Met-Gly-OH (13139-55-4)

Guidance literature:

Multi-step reaction with 2 steps

1: tributylphosphine / acetonitrile / 1 h / 27 °C

2: N-methylmorpholine N-oxide monohydrate (NMMNO) / acetonitrile; H₂O / 15 h / Ambient temperature

With tributylphosphine; 4-methylmorpholine N-oxide; In water; acetonitrile;

DOI:10.1246/bcsj.66.1566

Reference yield:

N-(benzyloxycarbonyl)-L-methionylglycine methyl ester (19519-01-8,54732-16-0) → Z-Met-Gly-OH (13139-55-4)

Guidance literature:

With sodium hydroxide; In water; acetone; at 20 ℃;

DOI:10.1021/acs.jmedchem.9b00823

upstream raw materials:

N-benzyloxycarbonyl-L-methionylglycine ethyl ester

Z-Met-Gly-O^tBu

glycine

Cbz-Met-OH

Downstream raw materials:

N-L-methionyl-glycine

Refernces

• 1、 Ghosh, Sunil Kumar,Singh, Usha,Chandha, Mohindra S.,Mamdapur, Vasant R.. "A One-Pot Peptide Synthesis via Se-phenyl Carboselenoate in Mixed Aqueous/Organic Solvent System". . p. 1566 - 1568. Retrieved 2007/10/02.