ethyl 2-(4-chlorobenzoyl)pent-4-ynoate

Base Information

• Chemical Name: ethyl 2-(4-chlorobenzoyl)pent-4-ynoate
• CAS No.: 100716-77-6
• Molecular Formula: C₁₄H₁₃ClO₃
• Molecular Weight: 264.708
• Mol file: 100716-77-6.mol

Synonyms:ethyl 2-(4-chlorobenzoyl)pent-4-ynoate

Chemical Property of ethyl 2-(4-chlorobenzoyl)pent-4-ynoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of ethyl 2-(4-chlorobenzoyl)pent-4-ynoate

There total 2 articles about ethyl 2-(4-chlorobenzoyl)pent-4-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

propargyl bromide (106-96-7) + ethyl (4-chlorobenzoyl)acetate (2881-63-2) → ethyl 2-(4-chlorobenzoyl)pent-4-ynoate (100716-77-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; toluene; at 20 ℃;

DOI:10.1016/j.tet.2017.04.030

Reference yield:

propargyl bromide (106-96-7) + ethyl (4-chlorobenzoyl)acetate (2881-63-2) → C17H15ClO3 + ethyl 2-(4-chlorobenzoyl)pent-4-ynoate (100716-77-6)

Guidance literature:

With potassium carbonate; sodium iodide; In acetone; at 20 ℃; Calcination; Milling;

DOI:10.1021/acs.joc.7b00736

Reference yield: 94.0%

ethyl 2-(4-chlorobenzoyl)pent-4-ynoate (100716-77-6) → ethyl 2-(4-chlorophenyl)-5-methylfuran-3-carboxylate

Guidance literature:

With iron(III) chloride; In 1,2-dichloro-ethane; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1016/j.tet.2017.04.030

upstream raw materials:

propargyl bromide

ethyl (4-chlorobenzoyl)acetate

Refernces

• 1、 Galenko, Alexey V.,Shakirova, Firuza M.,Galenko, Ekaterina E.,Novikov, Mikhail S.,Khlebnikov, Alexander F.. "Fe(II)/Au(I) Relay Catalyzed Propargylisoxazole to Pyridine Isomerization: Access to 6-Halonicotinates". . p. 5367 - 5379. Retrieved 2017.