2-Fluoro-6-methoxynaphthalene

Base Information

• Chemical Name: 2-Fluoro-6-methoxynaphthalene
• CAS No.: 13101-89-8
• Molecular Formula: C₁₁H₉FO
• Molecular Weight: 176.19
• Hs Code.: 2909309090
• DSSTox Substance ID: DTXSID101308206
• Nikkaji Number: J3.376.148A
• Mol file: 13101-89-8.mol

Synonyms:2-Fluoro-6-methoxynaphthalene;13101-89-8;Naphthalene, 2-fluoro-6-methoxy-;2-Methoxy-6-fluoronaphthalene;2-fluoro-6-methoxynapthalene;SCHEMBL7695294;UJQOYDMIMQIDBY-UHFFFAOYSA-N;DTXSID101308206

Chemical Property of 2-Fluoro-6-methoxynaphthalene

Chemical Property:

• Melting Point: 58-59℃ (hexane )
• Boiling Point: 135-140℃ (15 Torr)
• PSA: 9.23000
• LogP: 2.98750
• Storage Temp.: 2-8°C
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 176.063743068
• Heavy Atom Count: 13
• Complexity: 172

Purity/Quality:

98%Min ^*data from raw suppliers

2-Fluoro-6-methoxynaphthalene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C=C1)C=C(C=C2)F

Technology Process of 2-Fluoro-6-methoxynaphthalene

There total 7 articles about 2-Fluoro-6-methoxynaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Bromo-6-methoxynaphthalene (5111-65-9) → 6-Fluor-2-methoxy-naphthalin (13101-89-8)

Guidance literature:

2-Bromo-6-methoxynaphthalene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 0.5h; Inert atmosphere;

With N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; hexane; at -78 - 15 ℃; for 13h; Inert atmosphere;

Reference yield:

6-Methoxy-naphthalin-diazonium-(2) → 6-Fluor-2-methoxy-naphthalin (13101-89-8)

Guidance literature:

In paraffin; at 130 ℃;

DOI:10.1021/ja00978a038

Reference yield:

6-Methoxy-naphthalen-2-ylamine; compound with sulfuric acid → 6-Fluor-2-methoxy-naphthalin (13101-89-8)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) aq. HNO₂, (ii) aq. HPF₆

2: paraffin / 130 °C

In paraffin;

DOI:10.1021/ja00978a038

upstream raw materials:

6-methoxy-2-naphthylamine

N-(6-methoxynaphthalen-2-yl)acetamide

1-(6-methoxynaphthalen-2-yl)ethanone oxime

2-Bromo-6-methoxynaphthalene

Refernces