4,5-dimethyl-2-nitro-N-benzylaniline

Base Information

• Chemical Name: 4,5-dimethyl-2-nitro-N-benzylaniline
• CAS No.: 183492-69-5
• Molecular Formula: C₁₅H₁₆N₂O₂
• Molecular Weight: 256.304
• Mol file: 183492-69-5.mol

Synonyms:4,5-dimethyl-2-nitro-N-benzylaniline

Chemical Property of 4,5-dimethyl-2-nitro-N-benzylaniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,5-dimethyl-2-nitro-N-benzylaniline

There total 4 articles about 4,5-dimethyl-2-nitro-N-benzylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4,5-dimethyl-2-nitrobenzenamine (6972-71-0) + benzaldehyde (100-52-7) → 4,5-dimethyl-2-nitro-N-benzylaniline (183492-69-5)

Guidance literature:

4,5-dimethyl-2-nitrobenzenamine; benzaldehyde; With trifluoroacetic acid; In dichloromethane; for 0.333333h;

With sodium tris(acetoxy)borohydride; In dichloromethane;

DOI:10.1002/anie.201504455

Reference yield: 91.0%

4,5-dimethyl-2-nitro-N-(trifluoroacetyl)aniline (1799-80-0) + benzyl bromide (100-39-0) → 4,5-dimethyl-2-nitro-N-benzylaniline (183492-69-5)

Guidance literature:

With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In toluene; for 4h; Ambient temperature;

DOI:10.1080/00397919608003827

Reference yield:

benzylamine (100-46-9) → 4,5-dimethyl-2-nitro-N-benzylaniline (183492-69-5)

Guidance literature:

With i-Amyl alcohol;

DOI:10.1021/ja01228a031

upstream raw materials:

4,5-dimethyl-2-nitro-N-(trifluoroacetyl)aniline

benzyl bromide

benzylamine

4,5-dimethyl-2-nitrobenzenamine

Downstream raw materials:

lumichrome

4,5-dimethyl-1,2-phenylenediamine

N¹-benzyl-4,5-dimethylbenzene-1,2-diamine

Refernces

• 1、 Brown, Samuel A.,Rizzo, Carmelo J.. "A 'one-pot' phase transfer alkylation/hydrolysis of o-nitrotrifluoroacetanilides. A convenient route to N-alkyl o-phenylenediamines". . p. 4065 - 4080. Retrieved 2007/10/03.