Technology Process of (6S)-2,6-dimethyl-2-icosene
There total 1 articles about (6S)-2,6-dimethyl-2-icosene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-dodecylbromide;
With
magnesium;
In
tetrahydrofuran;
(R)-citronellyl tosylate;
With
dilithium tetrachlorocuprate;
In
tetrahydrofuran;
at -78 - 20 ℃;
Title compound not separated from byproducts;
DOI:10.1271/bbb.68.1768
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) O3, NaHCO3; 2.) NaBH4 / 1.) n-hexane, MeOH, CH2Cl2, -78 deg C, 10 h; 2.) n-hexane, MeOH, CH2Cl2, -78 deg C to 0 deg C, 3 h
2: 98 percent / pyridine / 12 h / 4 °C
With
sodium tetrahydroborate; sodium hydrogencarbonate; ozone;
In
pyridine;
DOI:10.1002/(SICI)1099-0690(199905)1999:5<981::AID-EJOC981>3.0.CO;2-3
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) O3, NaHCO3; 2.) NaBH4 / 1.) n-hexane, MeOH, CH2Cl2, -78 deg C, 10 h; 2.) n-hexane, MeOH, CH2Cl2, -78 deg C to 0 deg C, 3 h
2: 98 percent / pyridine / 12 h / 4 °C
3: 96 percent / NaI, NaHCO3 / acetone / 4 h / Heating
4: 87 percent / dimethylformamide / 10 h / Ambient temperature
5: 81 percent / n-BuLi / hexane; tetrahydrofuran; hexamethylphosphoric acid triamide / 10 h / Ambient temperature
With
sodium tetrahydroborate; n-butyllithium; sodium hydrogencarbonate; ozone; sodium iodide;
In
tetrahydrofuran; pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; N,N-dimethyl-formamide; acetone;
DOI:10.1002/(SICI)1099-0690(199905)1999:5<981::AID-EJOC981>3.0.CO;2-3
