C₂₉H₃₀F₃N₅O₂

Base Information

• Chemical Name: C₂₉H₃₀F₃N₅O₂
• CAS No.: 1613167-94-4
• Molecular Formula: C₂₉H₃₀F₃N₅O₂
• Molecular Weight: 537.585
• Mol file: 1613167-94-4.mol

Synonyms:C₂₉H₃₀F₃N₅O₂

Chemical Property of C₂₉H₃₀F₃N₅O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₉H₃₀F₃N₅O₂

There total 4 articles about C₂₉H₃₀F₃N₅O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]acetamide (1613169-19-9) + 5-bromoimidazo<1,2-a>pyridine (69214-09-1) → C29H30F3N5O2 (1613167-94-4)

Guidance literature:

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; at 100 ℃; for 16h;

Reference yield:

(4-bromophenoxy)acetic acid (1878-91-7) → C29H30F3N5O2 (1613167-94-4)

Guidance literature:

Multi-step reaction with 4 steps

1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 1 h / 0 - 20 °C

2: triethylamine / dichloromethane / 16 h / 0 - 20 °C

3: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 10 h / Inert atmosphere; Reflux

4: tricyclohexylphosphine; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 16 h / 100 °C

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; oxalyl dichloride; potassium acetate; triethylamine; tricyclohexylphosphine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

4-bromophenoxyacetyl chloride (16738-06-0) → C29H30F3N5O2 (1613167-94-4)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

2: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 10 h / Inert atmosphere; Reflux

3: tricyclohexylphosphine; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 16 h / 100 °C

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; triethylamine; tricyclohexylphosphine; In 1,4-dioxane; dichloromethane;

upstream raw materials:

(4-bromophenoxy)acetic acid

4-bromophenoxyacetyl chloride

2-(4-bromophenoxy)-N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}acetamide

N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]acetamide

Refernces