lithium (R)-(+)-2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenol

Base Information

• Chemical Name: lithium (R)-(+)-2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenol
• CAS No.: 1350462-15-5
• Molecular Formula: C₂₂H₃₀NO₂*Li
• Molecular Weight: 347.427
• Mol file: 1350462-15-5.mol

Synonyms:lithium (R)-(+)-2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenol

Chemical Property of lithium (R)-(+)-2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of lithium (R)-(+)-2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenol

There total 11 articles about lithium (R)-(+)-2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)-phenol (207679-81-0) → lithium (R)-(+)-2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenol (1350462-15-5)

Guidance literature:

With lithium hydroxide; In methanol; at 50 - 60 ℃;

Reference yield:

(-)-N,N-Diisopropyl-3-(2-benzyloxy-5-carboxyphenyl)-3-phenylpropylamine hydrochloride → lithium (R)-(+)-2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenol (1350462-15-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: borane-dimethyl sulfide complex / tetrahydrofuran / 25 - 50 °C

1.2: 0.5 h / 10 - 15 °C / Industry scale

2.1: raney nickel / methanol / 30 - 35 °C / Autoclave

3.1: tetrahydrofuran / 10 - 55 °C

4.1: potassium carbonate / toluene; water / 50 - 55 °C

5.1: lithium hydroxide / methanol / 50 - 60 °C

With borane-dimethyl sulfide complex; potassium carbonate; lithium hydroxide; raney nickel; In tetrahydrofuran; methanol; water; toluene;

Reference yield:

(-)-N,N-diisopropyl-3-(2-benzyloxy-5-hydroxymethylphenyl)-3-phenylpropylamine (250214-39-2,156755-36-1) → lithium (R)-(+)-2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenol (1350462-15-5)

Guidance literature:

Multi-step reaction with 4 steps

1: raney nickel / methanol / 30 - 35 °C / Autoclave

2: tetrahydrofuran / 10 - 55 °C

3: potassium carbonate / toluene; water / 50 - 55 °C

4: lithium hydroxide / methanol / 50 - 60 °C

With potassium carbonate; lithium hydroxide; raney nickel; In tetrahydrofuran; methanol; water; toluene;

upstream raw materials:

(R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)-phenol

(-)-N,N-diisopropyl-3-(2-benzyloxy-5-hydroxymethylphenyl)-3-phenylpropylamine

RS-N,N-diisopropyl-3-(2-hydroxy-5-(hydroxymethyl)phenyl)-3-phenylpropylamine

6-bromo-4-phenyl-3,4-dihydro-2H-chromen-2-one

Refernces

• 1、 -. "PROCESS FOR PREPARATION OF PHENOLIC MONOESTERS OF HYDROXYMETHYL PHENOLS". Page/Page column 9. . Retrieved 2011/11/30.