PYRROLIDINE-3-CARBONITRILE

Base Information

• Chemical Name: PYRROLIDINE-3-CARBONITRILE
• CAS No.: 10603-53-9
• Molecular Formula: C5H8N2
• Molecular Weight: 96.1319
• Hs Code.: 2933990090
• Mol file: 10603-53-9.mol

Synonyms:3-Cyanopyrrolidine;

Chemical Property of PYRROLIDINE-3-CARBONITRILE

Chemical Property:

• Vapor Pressure: 0.208mmHg at 25°C
• Refractive Index: 1.477
• Boiling Point: 208.93 °C at 760 mmHg
• PKA: 8.58±0.10(Predicted)
• Flash Point: 80.158 °C
• PSA: 35.82000
• Density: 1.01g/cm³
• LogP: 0.44828
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

Pyrrolidine-3-carbonitrile ^*data from reagent suppliers

Safty Information:

• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PYRROLIDINE-3-CARBONITRILE

There total 2 articles about PYRROLIDINE-3-CARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-cyanopyrrolidine-1-carboxylic acid tert-butyl ester (476493-40-0) → racemic pyrrolidine-3-carbonitrile (10603-53-9)

Guidance literature:

3-cyanopyrrolidine-1-carboxylic acid tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; methanol; for 3h;

With ammonia; In methanol;

Reference yield:

→ racemic pyrrolidine-3-carbonitrile (10603-53-9)

Guidance literature:

RBr, KCN;

Reference yield: 80.0%

3,4-difluoronitrobenzene (369-34-6) + racemic pyrrolidine-3-carbonitrile (10603-53-9) → 3-Fluoro-4-(3-cyanopyrrolidin-1-yl)nitrobenzene (1202878-54-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 20h; Inert atmosphere;

upstream raw materials:

3-cyanopyrrolidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

3-Fluoro-4-(3-cyanopyrrolidin-1-yl)nitrobenzene

C₂₄H₂₀FN₇O

1-(3-aminopropyl)pyrrolidine-3-carbonitrile

Refernces

• 1、 -. "PYRIDINE AND PYRIMIDINE BASED COMPOUNDS AS WNT SIGNALING PATHWAY INHIBITORS FOR THE TREATMENT OF CANCER". Page/Page column 36. . Retrieved 2010/04/28.