Rivaroxaban Impurity 55

Base Information Edit

Chemical Name:Rivaroxaban Impurity 55
CAS No.:1384257-81-1
Molecular Formula:C₈H₉Cl₂NO₂S
Molecular Weight:254.137
Hs Code.:
Mol file:1384257-81-1.mol

Synonyms:N-[(2S)-3-chloro-2-hydroxypropyl]-5-chlorothiophene-2-carboxamide

Suppliers and Price of Rivaroxaban Impurity 55

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-Chloro-N-((2S)-3-chloro-2-hydroxypropyl)thiophene-2-carboxamide
250mg
$ 495.00

Total 3 raw suppliers

Chemical Property of Rivaroxaban Impurity 55 Edit

Chemical Property:

Solubility.:Chloroform, DCM

Purity/Quality:

99% ^*data from raw suppliers

5-Chloro-N-((2S)-3-chloro-2-hydroxypropyl)thiophene-2-carboxamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 5-Chloro-N-((2S)-3-chloro-2-hydroxypropyl)thiophene-2-carboxamide is an intermediate in the synthesis of Rivaroxaban (R538000) related compounds.

Technology Process of Rivaroxaban Impurity 55

There total 4 articles about Rivaroxaban Impurity 55 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 24065-33-6
5-Chlorothiophene-2-carboxylic acid

: 34839-13-9,54798-66-2
(S)-1-amino-3-chloro-2-propanol hydrochloride

: 1384257-81-1
N-[(2S)-3-chloro-2-hydroxypropyl]-5-chlorothiophene-2-carboxamide

Guidance literature:: 5-Chlorothiophene-2-carboxylic acid; With bis(trichloromethyl) carbonate; In N,N-dimethyl-formamide; toluene; at 50 ℃;

(S)-1-amino-3-chloro-2-propanol hydrochloride; In water; N,N-dimethyl-formamide; toluene; at 5 - 20 ℃;

Reference yield: 86.22%

: 42518-98-9
5-chlorothiophene-2-carbonyl chloride

: 34839-13-9,54798-66-2
(2S)-1-amino-3-chloropropan-2-ol hydrogen chloride

: 1384257-81-1
N-[(2S)-3-chloro-2-hydroxypropyl]-5-chlorothiophene-2-carboxamide

Guidance literature:: (2S)-1-amino-3-chloropropan-2-ol hydrogen chloride; With sodium hydrogencarbonate; In water; at 25 - 30 ℃; for 0.5h;

5-chlorothiophene-2-carbonyl chloride; In water; toluene; at 25 - 30 ℃; for 5h;