4-BROMO-3,5-DIPHENYLISOXAZOLE

Base Information

• Chemical Name: 4-BROMO-3,5-DIPHENYLISOXAZOLE
• CAS No.: 10557-78-5
• Molecular Formula: C15H10 Br N O
• Molecular Weight: 300.154
• Hs Code.: 2934999090
• Mol file: 10557-78-5.mol

Synonyms:4-Bromo-3,5-diphenylisoxazole

Chemical Property of 4-BROMO-3,5-DIPHENYLISOXAZOLE

Chemical Property:

• Melting Point: 132.5-133.5 °C
• Boiling Point: 410.5±40.0 °C(Predicted)
• PKA: -5.17±0.10(Predicted)
• PSA: 26.03000
• Density: 1.414±0.06 g/cm3(Predicted)
• LogP: 4.77110
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Bromo-3,5-diphenylisoxazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BROMO-3,5-DIPHENYLISOXAZOLE

There total 14 articles about 4-BROMO-3,5-DIPHENYLISOXAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-azido-2-bromo-1,3-diphenylpropenone → 3,5-diphenyl-4-bromoisoxazole (10557-78-5)

Guidance literature:

In toluene; for 7h; Heating;

DOI:10.1055/s-2002-23542

Reference yield: 92.0%

1,2-diphenyl-cyclopropane (29881-14-9) → 3,5-diphenyl-4-bromoisoxazole (10557-78-5)

Guidance literature:

1,2-diphenyl-cyclopropane; With nitrosylsulfuric acid; nitromethane; at 20 ℃; for 1h;

With tetramethylammonium bromide;

DOI:10.1021/acs.joc.0c02106

Reference yield: 89.0%

3,5-diphehylisoxazole (2039-49-8) → 3,5-diphenyl-4-bromoisoxazole (10557-78-5)

Guidance literature:

With nitrosylsulfuric acid; nitromethane; tetramethylammonium bromide; at 20 ℃; for 1h; Reagent/catalyst;

DOI:10.1021/acs.joc.0c02106

upstream raw materials:

3,5-diphehylisoxazole

(Z)-2-Bromo-1,3-diphenyl-propenone oxime

(Z)-1,3-diphenylprop-2-yn-1-one O-methyl oxime

1,3-diphenyl-2-propynone

Downstream raw materials:

triphenylizoxazole

Refernces

• 1、 Pinho e Melo, Teresa M. V. D.,Lopes, Cláudia S. J.,Rocha Gonsalves, António M. D'A.,Storr, Richard C.. "Reactivity of 2-halo-2H-azirines. Part II. Thermal ring expansion reactions: Synthesis of 4-haloisoxazoles". . p. 605 - 608. Retrieved 2002.
• 2、 Sun, Yadong,Abdukader, Ablimit,Zhang, Haiyan,Yang, Wanle,Liu, Chenjiang. "Copper-catalyzed aerobic oxidative C-O bond formation for the synthesis of 3,5-disubstituted isoxazoles from enone oximes". . p. 55786 - 55789. Retrieved 2017/12/26.