2''-HYDROXY-3,4,4'',6''-TETRAMETHOXYCHALCONE

Base Information

• Chemical Name: 2''-HYDROXY-3,4,4'',6''-TETRAMETHOXYCHALCONE
• CAS No.: 10496-67-0
• Molecular Formula: C19H20 O6
• Molecular Weight: 344.364
• Hs Code.: 2914509090
• Mol file: 10496-67-0.mol

Synonyms:Chalcone,2'-hydroxy-3,4,4',6'-tetramethoxy- (7CI,8CI); 2'-Hydroxy-3,4,4',6'-tetramethoxychalcone

Chemical Property of 2''-HYDROXY-3,4,4'',6''-TETRAMETHOXYCHALCONE

Chemical Property:

• PSA: 74.22000
• LogP: 3.32270

Purity/Quality:

98%,99%, ^*data from raw suppliers

2'-Hydroxy-3,4,4',6'-tetramethoxychalcone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2''-HYDROXY-3,4,4'',6''-TETRAMETHOXYCHALCONE

There total 10 articles about 2''-HYDROXY-3,4,4'',6''-TETRAMETHOXYCHALCONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.1%

2-hydroxy-4,6-dimethoxyacetophenone (90-24-4) + 3,4-dimethoxy-benzaldehyde (120-14-9) → 3-(3,4-dimethoxyphenyl)-1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-en-1-one (10496-67-0,114021-60-2)

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

DOI:10.14233/ajchem.2016.19613

Reference yield: 71.0%

1-(2,4,6-trimethoxyphenyl)-3-(3,4-dimethoxyphenyl)propenone (76650-20-9) → 3-(3,4-dimethoxyphenyl)-1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-en-1-one (10496-67-0,114021-60-2)

Guidance literature:

With aluminum (III) chloride; In acetonitrile; at 80 ℃; for 4h; Inert atmosphere;

Reference yield: 61.0%

dimethyl sulfate (77-78-1) + hesperetin (520-33-2,41001-90-5,69097-99-0) → 3-(3,4-dimethoxyphenyl)-1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-en-1-one (10496-67-0,114021-60-2)

Guidance literature:

With potassium carbonate; In acetone; at 60 - 65 ℃; for 12h; regioselective reaction; Inert atmosphere;

DOI:10.3184/174751914X14031988231263

upstream raw materials:

2-hydroxy-4,6-dimethoxyacetophenone

3,4-dimethoxy-benzaldehyde

2,4,6-trihydroxyacetophenone

dimethyl sulfate

Downstream raw materials:

methyl 3,4-dimethoxybenzoate

1-(2,4,6-trimethoxyphenyl)-3-(3,4-dimethoxyphenyl)propenone

(Z)-2-(3,4-dimethoxybenzylidene)-4,6-dimethoxybenzofuran-3(2H)-one

3,4-dimethoxy-benzaldehyde

Refernces

• 1、 Freitas, Marisa,Ribeiro, Daniela,Tomé, Sara M.,Silva, Artur M.S.,Fernandes, Eduarda. "Synthesis of chlorinated flavonoids with anti-inflammatory and pro-apoptotic activities in human neutrophils". . p. 153 - 164. Retrieved 2014.
• 2、 Rambabu,Kumari,Baby Ramana,Ramani,Subbaraju,Hari Babu. "An improved synthesis of apigenin and luteolin". . p. 1139 - 1143. Retrieved 2016.
• 3、 -. "Hydroxyaurone derivative as well as preparation method and application thereof". . . Retrieved 2021/07/14.