2-TOLYLISOCYANIDE 95

Base Information

• Chemical Name: 2-TOLYLISOCYANIDE 95
• CAS No.: 10468-64-1
• Molecular Formula: C8H7 N
• Molecular Weight: 117.15
• Hs Code.: 2926909090
• Mol file: 10468-64-1.mol

Synonyms:o-Tolylisocyanide (6CI,7CI,8CI); 1-Isocyano-2-methylbenzene; 2-Methylphenylisocyanide; 2-Tolyl isocyanide; o-Methylphenyl isocyanide

Chemical Property of 2-TOLYLISOCYANIDE 95

Chemical Property:

• Refractive Index: n20/D 1.5140(lit.)
• Boiling Point: 36-38 °C0.2 mm Hg(lit.)
• Flash Point: 144 °F
• PSA: 0.00000
• Density: 0.953 g/mL at 25 °C(lit.)
• LogP: 1.77650

Purity/Quality:

98%,99%, ^*data from raw suppliers

PN100388:2-Methylphenylisocyanide 95 ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-TOLYLISOCYANIDE 95

There total 11 articles about 2-TOLYLISOCYANIDE 95 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2'-methylformanilide (94-69-9) → o-tolyl isocyanide (10468-64-1)

Guidance literature:

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In ethyl acetate; at 55 ℃; for 3h;

Reference yield:

N-o-tolyl-formimidic acid ethyl ester (4943-59-3) → o-tolyl isocyanide (10468-64-1) + 2-Methylbenzonitrile (529-19-1)

Guidance literature:

With kieselguhr; at 300 ℃; under 16 Torr;

Reference yield:

N-o-tolyl-formimidic acid ethyl ester (4943-59-3) → o-tolyl isocyanide (10468-64-1) + 2-Methylbenzonitrile (529-19-1)

Guidance literature:

at 300 ℃; under 16 Torr;

upstream raw materials:

2,3-Lutidine

chloroform

2'-methylformanilide

N-o-tolyl-formimidic acid ethyl ester

Downstream raw materials:

2'-methylformanilide

2-Methylbenzonitrile

(2-methylphenyl)carbonimidic dichloride

2-methylphenylthioformamide

Refernces

• 1、 Yuan, Yao,Dong, Wu-Heng,Gao, Xiao-Shuang,Xie, Xiao-Min,Zhang, Zhao-Guo. "Visible-light-induced radical cascade cyclization of oxime esters and aryl isonitriles: Synthesis of cyclopenta[: B] quinoxalines". supporting information. p. 11900 - 11903. Retrieved 2019/10/11.
• 2、 Yuan, Yao,Dong, Wuheng,Gao, Xiaoshuang,Gao, Huang,Xie, Xiaomin,Zhang, Zhaoguo. "Visible-Light-Induced Radical Cascade Cyclization: Synthesis of the ABCD Ring Cores of Camptothecins". supporting information. p. 2840 - 2846. Retrieved 2018/03/09.