2-(2-Naphthyl)-2-hydroxypropanoic acid

Base Information

• Chemical Name: 2-(2-Naphthyl)-2-hydroxypropanoic acid
• CAS No.: 10441-53-9
• Molecular Formula: C13H12O3
• Molecular Weight: 216.236
• Hs Code.: 2918199090
• Mol file: 10441-53-9.mol

Synonyms:2-(2-Naphthyl)-2-hydroxypropanoic acid

Chemical Property of 2-(2-Naphthyl)-2-hydroxypropanoic acid

Chemical Property:

• PSA: 57.53000
• LogP: 2.13190

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-(2-Hydroxy-1-naphthyl)propanoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-Naphthyl)-2-hydroxypropanoic acid

There total 10 articles about 2-(2-Naphthyl)-2-hydroxypropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

splitomicin (5690-03-9) → 3-(2-hydroxynaphthalen-1-yl)propanoic acid (10441-53-9)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran;

DOI:10.1021/jm030473r

Reference yield: 85.0%

ethyl 3-(2-hydroxynaphthalen-1-yl)propanoate (80515-84-0) → 3-(2-hydroxynaphthalen-1-yl)propanoic acid (10441-53-9)

Guidance literature:

With potassium hydroxide; In ethanol; for 2h; Ambient temperature;

DOI:10.1021/jo00345a009

Reference yield:

3-(2-hydroxynaphthalen-1-yl)propanenitrile (14233-73-9) → 3-(2-hydroxynaphthalen-1-yl)propanoic acid (10441-53-9)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/ja01186a036

upstream raw materials:

3-(2-hydroxynaphthalen-1-yl)propanenitrile

ethyl 3-(2-hydroxynaphthalen-1-yl)propanoate

3H-benzo[f]chromen-3-one

splitomicin

Downstream raw materials:

3-(2-phenylnaphthalen-1-yl)propanoic acid

ethyl 3-(2-phenylnaphthalen-1-yl)propanoate

4-(4-fluorophenyl)-1H-phenalen-1-one

4-(4-fluorophenyl)-2,3-dihydro-1H-phenalen-1-one

Refernces

• 1、 Furman et al.. "-". . p. 1450,1452. Retrieved 1960.
• 2、 Uyanik, Muhammet,Yasui, Takeshi,Ishihara, Kazuaki. "Chiral Hypervalent Organoiodine-Catalyzed Enantioselective Oxidative Spirolactonization of Naphthol Derivatives". . p. 11946 - 11953. Retrieved 2017/11/24.
• 3、 Cano, Marisol,Rojas, Carlos,Hidalgo, William,Sáez, Jairo,Gil, Jesús,Schneider, Bernd,Otálvaro, Felipe. "Improved synthesis of 4-phenylphenalenones: The case of isoanigorufone and structural analogs". . p. 351 - 354. Retrieved 2013/02/25.