METHYL 6-FORMYLNICOTINATE

Base Information

• Chemical Name: METHYL 6-FORMYLNICOTINATE
• CAS No.: 10165-86-3
• Molecular Formula: C8H7NO3
• Molecular Weight: 165.148
• Hs Code.: 29333990
• Mol file: 10165-86-3.mol

Synonyms:Nicotinicacid, 6-formyl-, methyl ester (7CI,8CI);6-Formylnicotinic acid methyl ester;6-Formylpyridine-3-carboxylic acid methyl ester;Methyl 6-formylnicotinate;Methyl 6-formylpyridine-3-carboxylate;

Chemical Property of METHYL 6-FORMYLNICOTINATE

Chemical Property:

• Vapor Pressure: 0.00591mmHg at 25°C
• Melting Point: 115-116.7 °C
• Refractive Index: 1.561
• Boiling Point: 272.9 °C at 760 mmHg
• PKA: 1.68±0.10(Predicted)
• Flash Point: 118.9 °C
• PSA: 56.26000
• Density: 1.249 g/cm³
• LogP: 0.68070
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%, ^*data from raw suppliers

Methyl 6-formylnicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-39-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 6-FORMYLNICOTINATE

There total 1 articles about METHYL 6-FORMYLNICOTINATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methyl 6-(hydroxymethyl)nicotinate (56026-36-9) → methyl 6-formylpyridine-3-carboxylate (10165-86-3)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 20 ℃; for 4h;

Reference yield: 81.0%

4-methoxy-aniline (104-94-9) + methyl 6-formylpyridine-3-carboxylate (10165-86-3) → methyl 6-(((4-methoxyphenyl)amino)methyl)nicotinate

Guidance literature:

4-methoxy-aniline; methyl 6-formylpyridine-3-carboxylate; With acetic acid; In dichloromethane; at 20 ℃; for 0.5h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 12h;

Reference yield: 51.0%

4-(hydrazinecarbothioamido)-N-(2-(2-methyl-1H-indol-3-yl)ethyl)benzamide + methyl 6-formylpyridine-3-carboxylate (10165-86-3) → C27H26N6O3S

Guidance literature:

With acetic acid; In ethanol; at 20 ℃;

DOI:10.1016/j.ejmech.2020.112970

upstream raw materials:

methyl 6-(hydroxymethyl)nicotinate

Downstream raw materials:

6-(5'-methoxycarbonyl-2'-pyridyl)-3-phenyl-1,2,4-triazine

3-(5-methoxycarbonyl-2-pyridyl)-6-(4-methylphenyl)-1,2,4-triazine

6-(5'-methoxycarbonyl-2'-pyridyl)-3-(4''-methoxyphenyl)-1,2,4-triazine

6-(piperidin-1-yl)methylnicotinic acid methyl ester

Refernces

• 1、 -. "MODULATORS OF THE INTEGRATED STRESS PATHWAY". Page/Page column 541-542. . Retrieved 2019/05/22.
• 2、 -. "A class of 2, 3 - dihydronaphth block pyrimidine analogs, its synthetic method, pharmaceutical composition and use thereof". Paragraph 0234-0236. . Retrieved 2017/07/22.