N-Acetyl-DL-histidine, Hydrate

Base Information

• Chemical Name: N-Acetyl-DL-histidine, Hydrate
• CAS No.: 10101-30-1
• Molecular Formula: C8H11 N3 O3
• Molecular Weight: 197.194
• Hs Code.: 2933290090
• Mol file: 10101-30-1.mol

Synonyms:DL-Histidine,N-acetyl-; Histidine, N-acetyl-, DL- (8CI); N-Acetyl-DL-histidine

Chemical Property of N-Acetyl-DL-histidine, Hydrate

Chemical Property:

• Melting Point: 144-145 °C
• Boiling Point: 620.2±50.0 °C(Predicted)
• PKA: 3.16±0.10(Predicted)
• PSA: 104.31000
• Density: 1.366±0.06 g/cm3(Predicted)
• LogP: -0.13190

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-acetyl-Histidine 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Acetyl-DL-histidine, Hydrate

There total 4 articles about N-Acetyl-DL-histidine, Hydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

acetic anhydride (108-24-7) + L-Histidine (71-00-1) → N-acetylhistidine (10101-30-1)

Guidance literature:

In acetic acid; at 100 ℃; for 0.05h;

DOI:10.1002/jhet.5570230351

Reference yield:

acetyl chloride (75-36-5) + D,L-histidine (71-00-1) → N-acetylhistidine (10101-30-1)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; water; at 20 ℃; Inert atmosphere;

DOI:10.1021/ol8022193

Reference yield:

acetic anhydride (108-24-7) + L-histidine (71-00-1) → N-acetylhistidine (10101-30-1)

Guidance literature:

With acetic acid; Dampft unter vermindertem Druck ein, erwaermt nochmals mit Acetanhydrid in Eisessig und dampft wieder ein;

upstream raw materials:

acetic anhydride

L-histidine

L-Histidine

acetyl chloride

Downstream raw materials:

D-histidin

N₃-Methyl-N^α-acetyl-4-nitrohistidine methyl ester

L-histidine

N^α-acetyl-D-histidine

Refernces

• 1、 -. "Composition containing a penem or carbapenem antibiotic and the use of the same". . . Retrieved 2008/06/13.
• 2、 Pedroso,Grandas,Ludevid,Giralt. "Determination of the preferred tautomeric form of 4-nitrohistidine". . p. 921 - 924. Retrieved 2007/10/02.