4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester

Base Information

• Chemical Name: 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester
• CAS No.: 1181267-38-8
• Molecular Formula: C₂₉H₃₉N₃O₃
• Molecular Weight: 477.647
• Mol file: 1181267-38-8.mol

Synonyms:4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester

Chemical Property of 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester

There total 35 articles about 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-methyl-2-(4-(2-oxoethyl)phenyl)propionic acid methyl ester + 1-(2-ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole (110963-63-8) → 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester (1181267-38-8)

Guidance literature:

2-methyl-2-(4-(2-oxoethyl)phenyl)propionic acid methyl ester; 1-(2-ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole; In tetrahydrofuran; at 20 ℃; for 4h;

With sodium tetrahydroborate; In tetrahydrofuran; for 4h; Reagent/catalyst;

Reference yield: 92.0%

2-[4-(2-chloroethyl)phenyl]-2-methylpropionic acid methyl ester (1181267-33-3) + 1-(2-ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole (110963-63-8) → 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester (1181267-38-8)

Guidance literature:

With sodium carbonate; sodium iodide; In water; at 90 ℃; for 24h; Temperature;

Reference yield: 92.0%

Methyl isobutyrate (547-63-7,133320-07-7,67505-84-4) + 2-{1-[2-(4-Chloro-phenyl)-ethyl]-piperidin-4-yl}-1-(2-ethoxy-ethyl)-1H-benzoimidazole → 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester (1181267-38-8)

Guidance literature:

Methyl isobutyrate; With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; sodium hexamethyldisilazane; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; zinc dibromide; In tetrahydrofuran; toluene; at 20 - 60 ℃; for 0.0833333h; Inert atmosphere;

2-{1-[2-(4-Chloro-phenyl)-ethyl]-piperidin-4-yl}-1-(2-ethoxy-ethyl)-1H-benzoimidazole; In tetrahydrofuran; toluene; at 80 ℃; for 20h; Reagent/catalyst; Solvent; Temperature; Concentration; Catalytic behavior; Inert atmosphere;

upstream raw materials:

2-Ethoxyethyl methanesulphonate

2-(4-{2-[4-(1H-benzoimidazol-2-yl)-piperidin-1-yl]-ethyl}phenyl)-2-methyl-propionic acid methyl ester

tert-butyl 4-(1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate

2-methyl-2-(4-(2-hydroxyethyl)phenyl)propionic acid methyl ester

Downstream raw materials:

Bilastine

Refernces

• 1、 -. "Preparation method of bilastine". . . Retrieved 2020/04/17.
• 2、 Kommera, Rajashekar,Yerrabelly, Jayaprakash Rao,Kasireddy, Venkateshwarreddy,Ghojala, Venkat Reddy,Singavarapu, Adilakshmi,Rebelli, Pradeep. "A new and competitive synthetic approach for an antihistamine agent, bilastine". . p. 815 - 821. Retrieved 2018/11/06.