5-BROMO-2-METHYL-1H-BENZIMIDAZOLE

Base Information

• Chemical Name: 5-BROMO-2-METHYL-1H-BENZIMIDAZOLE
• CAS No.: 1964-77-8
• Molecular Formula: C8H7BrN2
• Molecular Weight: 211.061
• Hs Code.: 2933990090
• Mol file: 1964-77-8.mol

Synonyms:1H-Benzimidazole,5-bromo-2-methyl- (9CI);Benzimidazole, 5(or 6)-bromo-2-methyl- (6CI,7CI);Benzimidazole, 5-bromo-2-methyl- (8CI);2-Methyl-5-bromobenzimidazole;5-Bromo-2-methylbenzimidazole;

Chemical Property of 5-BROMO-2-METHYL-1H-BENZIMIDAZOLE

Chemical Property:

• Vapor Pressure: 3.66E-06mmHg at 25°C
• Melting Point: 214-215 °C
• Refractive Index: 1.696
• Boiling Point: 397.3 °C at 760 mmHg
• PKA: 10.50±0.10(Predicted)
• Flash Point: 194.1 °C
• PSA: 28.68000
• Density: 1.654 g/cm³
• LogP: 2.63380
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Bromo-2-methylbenzoimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-2-METHYL-1H-BENZIMIDAZOLE

There total 26 articles about 5-BROMO-2-METHYL-1H-BENZIMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

Trimethyl orthoacetate (1445-45-0) + 4-Bromo-2-nitroaniline (875-51-4) → 5-bromo-2-methylbenzimidazole (1964-77-8)

Guidance literature:

With indium; acetic acid; In ethyl acetate; for 4h; Reflux; Inert atmosphere;

DOI:10.1016/j.tet.2011.08.017

Reference yield: 90.0%

2-Methyl-1H-benzimidazole (615-15-6) → 5-bromo-2-methylbenzimidazole (1964-77-8)

Guidance literature:

With N-Bromosuccinimide; silica gel; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/S0040-4039(86)80045-4

Reference yield: 89.0%

2',4'-dibromoacetanilide (23373-04-8) + acetamidine hydrochloride (124-42-5) → 5-bromo-2-methylbenzimidazole (1964-77-8)

Guidance literature:

With caesium carbonate; copper(I) bromide; In dimethyl sulfoxide; at 70 - 120 ℃; for 72h;

DOI:10.1021/jo8014984

upstream raw materials:

N-(4-bromo-2-nitrophenyl)acetamide

acetic anhydride

4-Bromo-benzene-1,2-diamine

2-Methyl-1H-benzimidazole

Refernces

• 1、 Yamini,Sharma, Saurabh,Das, Pralay. "Rhodium catalyzed 2-alkyl-benzimidazoles synthesis from benzene-1,2-diamines and tertiary alkylamines as alkylating agents". . . Retrieved 2021/05/17.
• 2、 Shaikh, Altab,Ravi, Owk,Pushpa Ragini,Sadhana, Nimma,Reddy Bathula, Surendar. "Benzimidazoles and benzothiazoles from styrenes and N-vinylimidazole via palladium catalysed oxidative C[dbnd]C and C[sbnd]N bond cleavage". supporting information. . Retrieved 2019/12/26.