3,3,4,4-TETRAFLUOROPYRROLIDINE HYDROCHLORIDE

Base Information

• Chemical Name: 3,3,4,4-TETRAFLUOROPYRROLIDINE HYDROCHLORIDE
• CAS No.: 1810-13-5
• Molecular Formula: C4H5 F4 N . Cl H
• Molecular Weight: 179.545
• Hs Code.: 2933990090
• Mol file: 1810-13-5.mol

Synonyms:Pyrrolidine,3,3,4,4-tetrafluoro-, hydrochloride (7CI,8CI,9CI);3,3,4,4-Tetrafluoropyrrolidine hydrochloride

Chemical Property of 3,3,4,4-TETRAFLUOROPYRROLIDINE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 85.1mmHg at 25°C
• Melting Point: 193-196 °C
• Boiling Point: 80.5°C at 760 mmHg
• Flash Point: 2.5°C
• PSA: 12.03000
• LogP: 1.99100
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility.: Soluble in water

Purity/Quality:

98%,99%, ^*data from raw suppliers

3,3,4,4-Tetrafluoropyrrolidine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,3,4,4-TETRAFLUOROPYRROLIDINE HYDROCHLORIDE

There total 3 articles about 3,3,4,4-TETRAFLUOROPYRROLIDINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-benzyl-3,3,4,4-tetrafluoropyrrolidine hydrochloride → (+/-)-3,3,4,4-tetrafluoropyrrolidine hydrochloride (1810-13-5)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 3h;

Reference yield: 85.0%

1-benzyl-3,3,4,4-tetrafluoro-pyrrolidine → (+/-)-3,3,4,4-tetrafluoropyrrolidine hydrochloride (1810-13-5)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1016/j.bmcl.2005.07.026

Reference yield: 68.0%

3,3,4,4-tetrafluorosuccinimide (377-33-3) → (+/-)-3,3,4,4-tetrafluoropyrrolidine hydrochloride (1810-13-5)

Guidance literature:

With hydrogenchloride; borane; In tetrahydrofuran;

DOI:10.1021/ja00543a027

upstream raw materials:

3,3,4,4-tetrafluorosuccinimide

Downstream raw materials:

3,4-difluoro-1H-pyrrole

(S)-[5-benzyloxycarbonylamino-1-(3,3,4,4-tetrafluoro-pyrrolidine-1-carbonyl)-pentyl]-carbamic acid tert-butyl ester

1-[2-fluoro-4-(3,3,4,4-tetrafluoropyrrolidin-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

1-[2-fluoro-3-(3,3,4,4-tetrafluoropyrrolidin-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Refernces

• 1、 -. "Synthesis method of 3,3,4,4-tetrafluoropyrrolidine". Paragraph 0017; 0018; 0022; 0023; 0027; 0028. . Retrieved 2018/04/21.
• 2、 Hulin, Bernard,Cabral, Shawn,Lopaze, Michael G.,Van Volkenburg, Maria A.,Andrews, Kim M.,Parker, Janice C.. "New fluorinated pyrrolidine and azetidine amides as dipeptidyl peptidase IV inhibitors". . p. 4770 - 4773. Retrieved 2007/10/03.