5,6,7,8-Tetrafluorobenzo-1,4-dioxane

Base Information

• Chemical Name: 5,6,7,8-Tetrafluorobenzo-1,4-dioxane
• CAS No.: 1743-87-9
• Molecular Formula: C₈H₄F₄O₂
• Molecular Weight: 208.112
• Hs Code.: 2932990090
• DSSTox Substance ID: DTXSID70380205
• Nikkaji Number: J2.776.733H
• Wikidata: Q82170324
• Mol file: 1743-87-9.mol

Synonyms:5,6,7,8-Tetrafluorobenzo-1,4-dioxane;1743-87-9;5,6,7,8-tetrafluoro-2,3-dihydro-1,4-benzodioxine;MFCD00229993;5,6,7,8-tetrafluoro-2,3-dihydrobenzo[b][1,4]dioxine;SCHEMBL3759393;5,6,7,8-tetrafluorobenzodioxane;DTXSID70380205;AKOS015853278;CS-0360635;FT-0619800;5,6,7,8-TETRAFLUOROBENZO-1,4-DIOXENE;2,3-Dihydro-5,6,7,8-tetrafluoro-1,4-benzodioxin;J-010985;5,6,7,8-TETRAFLUORO-2,3-DIHYDRO-BENZO(1,4)DIOXINE

Chemical Property of 5,6,7,8-Tetrafluorobenzo-1,4-dioxane

Chemical Property:

• Vapor Pressure: 0.86mmHg at 25°C
• Melting Point: 78-79°C
• Refractive Index: 1.459
• Boiling Point: 187.6°Cat760mmHg
• Flash Point: 73.7°C
• PSA: 18.46000
• Density: 1.539g/cm³
• LogP: 2.01420
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 0
• Exact Mass: 208.01474201
• Heavy Atom Count: 14
• Complexity: 194

Purity/Quality:

98%Min ^*data from raw suppliers

5,6,7,8-Tetrafluorobenzo-1,4-dioxane ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC2=C(O1)C(=C(C(=C2F)F)F)F

Technology Process of 5,6,7,8-Tetrafluorobenzo-1,4-dioxane

There total 4 articles about 5,6,7,8-Tetrafluorobenzo-1,4-dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(pentafluorophenoxy)ethanol (2192-55-4) → 5,6,7,8-tetrafluoro-1,4-benzodioxane (1743-87-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/j.jfluchem.2003.08.003

Reference yield:

Trimethyl-(2-pentafluorophenyloxy-ethoxy)-silane (159752-87-1) → 5,6,7,8-tetrafluoro-1,4-benzodioxane (1743-87-9)

Guidance literature:

With potassium fluoride;

DOI:10.1016/0022-1139(93)05008-O

Reference yield:

2-(pentafluorophenoxy)ethanol (2192-55-4) + ethylene glycol (107-21-1) → 5,6,7,8-tetrafluoro-1,4-benzodioxane (1743-87-9) + 6,7,9,10,16,17,19,20-octafluoro-1,4,11,14-tetraoxa<4,4>paracyclophane (127236-62-8)

Guidance literature:

With sodium amide; Yield given. Multistep reaction. Yields of byproduct given; 1.) liquid ammonia, 2.) from -40 to -33 deg C, 3 h;

upstream raw materials:

2-(pentafluorophenoxy)ethanol

ethylene glycol

Trimethyl-(2-pentafluorophenyloxy-ethoxy)-silane

Refernces

• 1、 Zhang, Y. F.,Kirchmeier, Robert L.,Shreeve, Jean'ne M.. "Reaction of hexafluorobenzene with trimethylsilyl ethers". . p. 287 - 292. Retrieved 2007/10/02.