(4-FLUORO-BENZYL)-PYRIDIN-2-YL-AMINE DIHYDROCHLORIDE

Base Information

• Chemical Name: (4-FLUORO-BENZYL)-PYRIDIN-2-YL-AMINE DIHYDROCHLORIDE
• CAS No.: 1692-02-0
• Molecular Formula: C12H11 F N2
• Molecular Weight: 202.231
• Hs Code.: 2933399090
• Mol file: 1692-02-0.mol

Synonyms:Pyridine,2-[(p-fluorobenzyl)amino]- (6CI,8CI)

Chemical Property of (4-FLUORO-BENZYL)-PYRIDIN-2-YL-AMINE DIHYDROCHLORIDE

Chemical Property:

• Boiling Point: 326.6±22.0 °C(Predicted)
• PKA: 6.21±0.10(Predicted)
• PSA: 24.92000
• Density: 1.210±0.06 g/cm3(Predicted)
• LogP: 4.50980

Purity/Quality:

99%min ^*data from raw suppliers

N-[(4-Fluorophenyl)methyl]pyridin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-FLUORO-BENZYL)-PYRIDIN-2-YL-AMINE DIHYDROCHLORIDE

There total 10 articles about (4-FLUORO-BENZYL)-PYRIDIN-2-YL-AMINE DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.83%

2-aminopyridine (504-29-0) + 1-chloromethyl-4-fluorobenzene (352-11-4) → N-(4-fluorobenzyl)pyridine-2-amine (1692-02-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; potassium iodide; In 5,5-dimethyl-1,3-cyclohexadiene; at 78 ℃;

Reference yield: 40.0%

[1-(4-Fluoro-phenyl)-meth-(Z)-ylidene]-pyridin-2-yl-amine → N-(4-fluorobenzyl)pyridine-2-amine (1692-02-0)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; at 25 ℃; for 4h;

DOI:10.1016/0223-5234(96)88217-1

Reference yield: 23.0%

2-aminopyridine (504-29-0) + 4-fluorobenzylic alcohol (459-56-3) → N-(4-fluorobenzyl)pyridine-2-amine (1692-02-0)

Guidance literature:

With [Co(PCP^Me-iPr)Cl]; potassium tert-butylate; In toluene; at 80 ℃; for 16h; Inert atmosphere; Green chemistry;

DOI:10.1021/acs.orglett.6b01647

upstream raw materials:

2-fluoropyridine

para-fluorobenzylamine

2-aminopyridine

N-(tert-butoxycarbonyl)-2-aminopyridine

Downstream raw materials:

N-(4-fluoro-benzyl)-N',N'-dimethyl-N-[2]pyridyl-ethylenediamine

8-fluoropyrido[1,2-a]benzimidazole

(5-bromo-pyridin-2-yl)-(4-fluoro-benzyl)-amine

Refernces

• 1、 -. "Dithioacetal-containing pyridopyrimidone derivative as well as preparation and application thereof". Paragraph 0120-0122. . Retrieved 2021/09/04.
• 2、 Mastalir, Matthias,St?ger, Berthold,Pittenauer, Ernst,Puchberger, Michael,Allmaier, Günter,Kirchner, Karl. "Air Stable Iron(II) PNP Pincer Complexes as Efficient Catalysts for the Selective Alkylation of Amines with Alcohols". . p. 3824 - 3831. Retrieved 2016/12/16.