Pyrimidine, 2-amino-4-chloro-5-fluoro- (7CI,8CI)

Base Information

• Chemical Name: Pyrimidine, 2-amino-4-chloro-5-fluoro- (7CI,8CI)
• CAS No.: 1683-75-6
• Molecular Formula: C4H3 Cl F N3
• Molecular Weight: 147.539
• Hs Code.: 2933599090
• Mol file: 1683-75-6.mol

Synonyms:Pyrimidine,2-amino-4-chloro-5-fluoro- (7CI,8CI)

Chemical Property of Pyrimidine, 2-amino-4-chloro-5-fluoro- (7CI,8CI)

Chemical Property:

• Melting Point: 110 °C (decomp)
• Boiling Point: 321.7°Cat760mmHg
• PKA: 1.92±0.10(Predicted)
• Flash Point: 148.3°C
• PSA: 51.80000
• Density: 1.564g/cm³
• LogP: 1.43250
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

4-Chloro-5-fluoropyrimidin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrimidine, 2-amino-4-chloro-5-fluoro- (7CI,8CI)

There total 3 articles about Pyrimidine, 2-amino-4-chloro-5-fluoro- (7CI,8CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

2,4-dichloro-5-fluoropyrimidine (2927-71-1) → 2-amino-4-chloro-5-fluoropyrimidine (1683-75-6)

Guidance literature:

With ammonium hydroxide; In tetrahydrofuran; at 0 ℃; Temperature; Green chemistry;

Reference yield: 17.0%

2-amino-5-fluoropyrimidin-4(5H)-one → 2-amino-4-chloro-5-fluoropyrimidine (1683-75-6)

Guidance literature:

With trichlorophosphate; for 4h; Heating;

Reference yield:

→ 2-amino-4-chloro-5-fluoropyrimidine (1683-75-6)

Guidance literature:

5-Fluor-4-hydroxy-2-aminopyrimidin, POCl3/ClSO3H (20h 90-110grad);

upstream raw materials:

2,4-dichloro-5-fluoropyrimidine

Refernces

• 1、 -. "Synthetic method of 2-amidogen-4-chlorine-5-fluorine pyrimidine". Paragraph 0005; 0012-0014. . Retrieved 2019/10/29.
• 2、 -. "ALKYNYL ALCOHOLS AS KINASE INHIBITORS". Page/Page column 48. . Retrieved 2010/01/30.