9-XANTHENECARBOXYLIC HYDRAZIDE

Base Information

• Chemical Name: 9-XANTHENECARBOXYLIC HYDRAZIDE
• CAS No.: 1604-08-6
• Molecular Formula: C14H12 N2 O2
• Molecular Weight: 240.26
• Hs Code.: 2932999099
• Mol file: 1604-08-6.mol

Synonyms:Xanthene-9-carboxylicacid, hydrazide (7CI,8CI)

Chemical Property of 9-XANTHENECARBOXYLIC HYDRAZIDE

Chemical Property:

• Melting Point: 247°C (dec.)
• Boiling Point: 451.5±45.0 °C(Predicted)
• PKA: 12.46±0.20(Predicted)
• PSA: 64.35000
• Density: 1.303±0.06 g/cm3(Predicted)
• LogP: 3.00530

Purity/Quality:

98%min ^*data from raw suppliers

9H-Xanthene-9-carbohydrazide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 9-XANTHENECARBOXYLIC HYDRAZIDE

There total 2 articles about 9-XANTHENECARBOXYLIC HYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

9H-xanthene-9-carboxylic acid methyl ester (39497-06-8) → 9H-xanthene-9-carboxylic acid hydrazide (1604-08-6)

Guidance literature:

With hydrazine hydrate; at 120 ℃; for 0.166667h; under 7500.75 Torr; Microwave irradiation;

DOI:10.5012/jkcs.2010.54.4.419

Reference yield:

xanthene-9-carboxylic acid (82-07-5) → 9H-xanthene-9-carboxylic acid hydrazide (1604-08-6)

Guidance literature:

With hydrazine hydrate; triethylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.833333h;

DOI:10.1080/00304940309355842

Reference yield: 78.0%

9H-xanthene-9-carboxylic acid hydrazide (1604-08-6) + salicylaldehyde (90-02-8) → (E)-N'-(2-hydroxybenzylidene)-9H-xanthene-9-carbohydrazide

Guidance literature:

In methanol; at 20 ℃; for 5h;

DOI:10.1039/c5ra26531b

upstream raw materials:

xanthene-9-carboxylic acid

9H-xanthene-9-carboxylic acid methyl ester

Downstream raw materials:

Boc-Tyr(OBn)-NHNH-CO-9H-Xanth

Refernces

• 1、 Albatal, Mona,Ghani, Mohamad Abdul,El-Faham, Ayman,Al-Hazimi, Hassan M.,Hammud, Hassan H.. "Microwave irradiation and diisopropylcarbodiimide (DIC)/7-aza-1- hydroxybenzotriazole (HOAt): A potent combination for synthesis of variuos hydrazide from N-protected amino acid and hydrazine". experimental part. p. 419 - 428. Retrieved 2010/11/04.