D-2-AMINO-1,1,1-TRIFLUORO-3-(METHYL)BUTANE

Base Information

• Chemical Name: D-2-AMINO-1,1,1-TRIFLUORO-3-(METHYL)BUTANE
• CAS No.: 1582-18-9
• Molecular Formula: C5H10F3N
• Molecular Weight: 141.136
• Hs Code.: 2921199990
• Mol file: 1582-18-9.mol

Synonyms:Propylamine,2-methyl-1-(trifluoromethyl)- (8CI);1,1,1-Trifluoro-3-methylbutan-2-amine;

Chemical Property of D-2-AMINO-1,1,1-TRIFLUORO-3-(METHYL)BUTANE

Chemical Property:

• Refractive Index: 1.36
• Boiling Point: 108.8 °C at 760 mmHg
• PKA: 5.66±0.50(Predicted)
• Flash Point: 29.2 °C
• Density: 1.07 g/cm³

Purity/Quality:

98% ^*data from raw suppliers

1,1,1-Trifluoro-3-methylbutan-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C,Xi
• Hazard Codes: C,Xi
• Statements: 10-34-36
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of D-2-AMINO-1,1,1-TRIFLUORO-3-(METHYL)BUTANE

There total 3 articles about D-2-AMINO-1,1,1-TRIFLUORO-3-(METHYL)BUTANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C5H8F3NO (1639939-94-8) → rac-1,1,1-trifluoro-3-methylbutan-2-amine (1582-18-9)

Guidance literature:

With hydrogen; In methanol; at 90 ℃; under 1500.15 Torr; Autoclave; Large scale;

DOI:10.14233/ajchem.2015.17863

Reference yield:

C12H14F3N (1589570-36-4) → rac-1,1,1-trifluoro-3-methylbutan-2-amine (1582-18-9)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; benzylamine; In toluene; at 90 ℃;

DOI:10.1039/c3ra40526e

Reference yield:

D,L-valine (516-06-3,25609-85-2,7004-03-7,921-10-8) → rac-1,1,1-trifluoro-3-methylbutan-2-amine (1582-18-9)

Guidance literature:

With sulfur tetrafluoride; hydrogen fluoride;

DOI:10.1021/jo01051a068

upstream raw materials:

D,L-valine

C₁₂H₁₄F₃N

C₅H₈F₃NO

Refernces

• 1、 Cheng, Guilin,Xia, Bo,Wu, Qi,Lin, Xianfu. "Chemoenzymatic dynamic kinetic resolution of α-trifluoromethylated amines: Influence of substitutions on the reversed stereoselectivity". . p. 9820 - 9828. Retrieved 2013/09/02.