1H-Inden-1-one, 2-chloro-2,3-dihydro-

Base Information

• Chemical Name: 1H-Inden-1-one, 2-chloro-2,3-dihydro-
• CAS No.: 1579-14-2
• Molecular Formula: C9H7 Cl O
• Molecular Weight: 166.607
• Hs Code.: 2914700090
• Mol file: 1579-14-2.mol

Synonyms:1-Indanone,2-chloro- (6CI,7CI,8CI); 2-Chloro-1-indanone; 2-Chloroindanone

Chemical Property of 1H-Inden-1-one, 2-chloro-2,3-dihydro-

Chemical Property:

• Melting Point: 38-39 °C
• Boiling Point: 278.0±29.0 °C(Predicted)
• PSA: 17.07000
• Density: 1.28±0.1 g/cm3(Predicted)
• LogP: 2.03280

Purity/Quality:

99% ^*data from raw suppliers

2-chloro-2,3-dihydro-1H-inden-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Inden-1-one, 2-chloro-2,3-dihydro-

There total 13 articles about 1H-Inden-1-one, 2-chloro-2,3-dihydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

inden-1-one (83-33-0) → 2-chloroindanone (1579-14-2,73908-22-2)

Guidance literature:

With (Dichloroiodo)benzene; In methanol; at 20 ℃;

DOI:10.1055/s-0029-1216856

Reference yield: 86.0%

inden-1-one (83-33-0) → 2-chloroindanone (1579-14-2,73908-22-2) + 2,2-dichloro-2,3-dihydro-1H-inden-1-one (17215-77-9)

Guidance literature:

With [bis(acetoxy)iodo]benzene; iron(III) chloride hexahydrate; In acetic acid; at 20 ℃; for 7h; Inert atmosphere;

DOI:10.1002/adsc.201700833

Reference yield: 83.0%

1-trimethylsilyloxy-3H-indene (31928-64-0) → 2-chloroindanone (1579-14-2,73908-22-2)

Guidance literature:

With tris(triphenylphosphine)ruthenium(II) chloride; trifluoromethane sulfonyl chloride; In benzene; at 120 ℃; for 7h;

DOI:10.1080/10426509708031590

upstream raw materials:

2-chloroindan-1-ol

inden-1-one

2,2-dichloro-2,3-dihydro-1H-inden-1-one

1-trimethylsilyloxy-3H-indene

Downstream raw materials:

methyl 5-chloro-1-oxo-2,3-dihydro-1H-indene-2-carboxylate

1-indene

Refernces

• 1、 Zhu, Yi-Wei,Shi, Yi-Xin. "Efficient Synthesis of α-Chloroketones Catalyzed by Fluorous Hydrazine-1,2-Bis(Carbothioate) Organocatalyst". . p. 570 - 574. Retrieved 2016.
• 2、 Daniliuc, Constantin G.,Gilmour, Ryan,Mück-Lichtenfeld, Christian,Neufeld, Jessica,Stünkel, Timo. "Trifluorinated Tetralins via I(I)/I(III)-Catalysed Ring Expansion: Programming Conformation by [CH2CH2] → [CF2CHF] Isosterism". supporting information. p. 13647 - 13651. Retrieved 2021/05/07.
• 3、 Tang, Shi-Zhong,Zhao, Wenshuang,Chen, Tao,Liu, Yang,Zhang, Xiao-Ming,Zhang, Fu-Min. "A Simple and Efficient Method for the Preparation of α-Halogenated Ketones Using Iron(III) Chloride and Iron(III) Bromide as Halogen Sources with Phenyliodonium Diacetate as Oxidant". supporting information. p. 4177 - 4183. Retrieved 2017/12/18.