2-Fluoro-6-bromobenzyl bromide

Base Information

• Chemical Name: 2-Fluoro-6-bromobenzyl bromide
• CAS No.: 1548-81-8
• Molecular Formula: C7H5Br2F
• Molecular Weight: 267.923
• Hs Code.: 2903999090
• Mol file: 1548-81-8.mol

Synonyms:1-Bromo-2-bromomethyl-3-fluorobenzene;Toluene, a,2-dibromo-6-fluoro- (7CI,8CI);2-Bromo-6-fluorobenzyl bromide;

Chemical Property of 2-Fluoro-6-bromobenzyl bromide

Chemical Property:

• Vapor Pressure: 0.037mmHg at 25°C
• Refractive Index: 1.583
• Boiling Point: 249 °C at 760 mmHg
• Flash Point: 104.4 °C
• PSA: 0.00000
• Density: 1.923 g/cm³
• LogP: 3.48310

Purity/Quality:

99% ^*data from raw suppliers

1-Bromo-2-(bromomethyl)-3-fluorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Fluoro-6-bromobenzyl bromide

There total 3 articles about 2-Fluoro-6-bromobenzyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(2-bromo-6-fluorophenyl)methanol (261723-33-5) → 1-bromo-2-(bromomethyl)-3-fluorobenzene (1548-81-8)

Guidance literature:

With pyridine; phosphorus tribromide; In chloroform; at 0 - 20 ℃;

Reference yield:

1-bromo-3-fluoro-2-methyl-benzene (1422-54-4) → 1-bromo-2-(bromomethyl)-3-fluorobenzene (1548-81-8)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide;

DOI:10.1021/jo01042a006

Reference yield:

3-bromo-2-methylaniline (55289-36-6) → 1-bromo-2-(bromomethyl)-3-fluorobenzene (1548-81-8)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) NaNO₂, aq. HCl, aq. HBF₄, (ii) (pyrolysis)

2: NBS, (PhCO)2O₂

With N-Bromosuccinimide; dibenzoyl peroxide;

DOI:10.1021/jo01042a006

upstream raw materials:

1-bromo-3-fluoro-2-methyl-benzene

3-bromo-2-methylaniline

(2-bromo-6-fluorophenyl)methanol

Downstream raw materials:

2-bromo-6-fluorobenzoic acid

1-bromo-2-(2-bromo-6-fluoro-benzyloxy)-4-fluoro-benzene

Refernces