N-{4-[4-(biphenyl-4-yl)-4-oxobutanamido]butyl}-5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamide

Base Information

• Chemical Name: N-{4-[4-(biphenyl-4-yl)-4-oxobutanamido]butyl}-5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamide
• CAS No.: 1284259-13-7
• Molecular Formula: C₃₅H₄₄N₂O₄
• Molecular Weight: 556.745
• Mol file: 1284259-13-7.mol

Synonyms:N-{4-[4-(biphenyl-4-yl)-4-oxobutanamido]butyl}-5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamide

Chemical Property of N-{4-[4-(biphenyl-4-yl)-4-oxobutanamido]butyl}-5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{4-[4-(biphenyl-4-yl)-4-oxobutanamido]butyl}-5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamide

There total 3 articles about N-{4-[4-(biphenyl-4-yl)-4-oxobutanamido]butyl}-5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

gemfibrozil (25812-30-0) + N-(4-aminobutyl)-4-(biphenyl-4-yl)-4-oxobutanamide (1284258-79-2) → N-{4-[4-(biphenyl-4-yl)-4-oxobutanamido]butyl}-5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamide (1284259-13-7)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.25h; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.01.068

Reference yield:

N-(4-azidobutyl)-4-(biphenyl-4-yl)-4-oxobutanamide (1284258-78-1) → N-{4-[4-(biphenyl-4-yl)-4-oxobutanamido]butyl}-5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamide (1284259-13-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 10% palladium on activated charcoal; hydrogen / methanol / 0.83 h

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / Inert atmosphere

With 10% palladium on activated charcoal; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.01.068

Reference yield:

3-(p-phenyl)benzoylpropionic acid (36330-85-5) → N-{4-[4-(biphenyl-4-yl)-4-oxobutanamido]butyl}-5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamide (1284259-13-7)

Guidance literature:

Multi-step reaction with 3 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / Inert atmosphere

2: 10% palladium on activated charcoal; hydrogen / methanol / 0.83 h

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / Inert atmosphere

With 10% palladium on activated charcoal; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.01.068

upstream raw materials:

N-(4-azidobutyl)-4-(biphenyl-4-yl)-4-oxobutanamide

gemfibrozil

N-(4-aminobutyl)-4-(biphenyl-4-yl)-4-oxobutanamide

3-(p-phenyl)benzoylpropionic acid

Refernces

• 1、 -. "CONSTRUCTION AND SCREENING OF SOLUTION-PHASE DERIVED LIBRARY OF FENBUFEN AND ETHACRYNIC ACID". Page/Page column 26. . Retrieved 2012/01/03.