1,2-Dimyristin, (R)-

Base Information

• Chemical Name: 1,2-Dimyristin, (R)-
• CAS No.: 1069-82-5
• Molecular Formula: C31H60 O5
• Molecular Weight: 512.814
• Hs Code.: 2915900090
• UNII: 77SU067V2A
• DSSTox Substance ID: DTXSID50452393
• Nikkaji Number: J152.205A
• Wikidata: Q27146926
• Mol file: 1069-82-5.mol

Synonyms:1,2-Dimyristin, (R)-;Myristin, 1,2-di-, D-;1069-82-5;2,3-Dimyristoyl-sn-glycerol;UNII-77SU067V2A;77SU067V2A;Tetradecanoic acid, 1-(hydroxymethyl)-1,2-ethanediyl ester, (R)-;Tetradecanoic acid, 1,1'-((1R)-1-(hydroxymethyl)-1,2-ethanediyl) ester;(R)-1,2-Dimyristin;2,3-dimyristin;(+)-D-1,2-Dimyristin;SCHEMBL2734752;2,3-ditetradecanoyl-sn-glycerol;CHEBI:77392;DTXSID50452393;2 3-DIMYRISTOYL-SN-GLYCEROL*;(2R)-3-hydroxypropane-1,2-diyl ditetradecanoate;DG 0:0/14:0/14:0;Q27146926;[(2R)-3-hydroxy-2-tetradecanoyloxypropyl] tetradecanoate

Chemical Property of 1,2-Dimyristin, (R)-

Chemical Property:

• Melting Point: 58-61 °C
• PSA: 72.83000
• LogP: 8.83590
• Storage Temp.: −20°C
• XLogP3: 11.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 30
• Exact Mass: 512.44407501
• Heavy Atom Count: 36
• Complexity: 480

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCCCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCCCCCCCC
• Isomeric SMILES: CCCCCCCCCCCCCC(=O)OC[C@@H](CO)OC(=O)CCCCCCCCCCCCC

Technology Process of 1,2-Dimyristin, (R)-

There total 2 articles about 1,2-Dimyristin, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1,2-di-O-myristoyl-3-O-benzyl-sn-glycerol (73083-33-7) → 1,2-di-O-myristoyl-sn-glycerol (1069-82-5,56270-93-0)

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal; In ethanol; at 20 ℃;

DOI:10.1021/ol062840+

Reference yield:

→ 1,2-di-O-myristoyl-sn-glycerol (1069-82-5,56270-93-0)

Guidance literature:

With cyclohexane; palladium; Hydrogenation;

Reference yield: 95.0%

1,2-di-O-myristoyl-sn-glycerol (1069-82-5,56270-93-0) + benzyl-N,N,N',N'-tetraisopropylphosphorodiamidite (108549-21-9) → (2S)-3-(((benzyloxy)(diisopropylamino)phosphanyl)oxy)propane-1,2-diyl ditetradecanoate

Guidance literature:

With 5H-tetrazole; In dichloromethane; acetonitrile; at 20 ℃; for 4h; Inert atmosphere; Molecular sieve;

DOI:10.1002/anie.202114858

upstream raw materials:

1,2-di-O-myristoyl-3-O-benzyl-sn-glycerol

Downstream raw materials:

L-α-Dimyristoylphosphatidic acid

Refernces

• 1、 Lee, Jong-Dae,Ueno, Manabu,Miyajima, Yusuke,Nakamura, Hiroyuki. "Synthesis of boron cluster lipids: Closo-dodecaborate as an alternative hydrophilic function of boronated liposomes for neutron capture therapy". . p. 323 - 326. Retrieved 2008/02/03.