2-Amino-2-(3,4-dihydroxyphenyl)acetic acid

Base Information

• Chemical Name: 2-Amino-2-(3,4-dihydroxyphenyl)acetic acid
• CAS No.: 138-62-5
• Molecular Formula: C8H9 N O4
• Molecular Weight: 183.16
• Hs Code.: 2922509090
• DSSTox Substance ID: DTXSID50937079
• Nikkaji Number: J794.606F
• Wikidata: Q72466914
• ChEMBL ID: CHEMBL4074483
• Mol file: 138-62-5.mol

Synonyms:3,4-dihydroxyphenylglycine

Chemical Property of 2-Amino-2-(3,4-dihydroxyphenyl)acetic acid

Chemical Property:

• PSA: 103.78000
• Density: 1.55
• LogP: 0.88250
• XLogP3: -3.1
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 183.05315777
• Heavy Atom Count: 13
• Complexity: 197

Purity/Quality:

99% ^*data from raw suppliers

2-(3,4-Dihydroxyphenyl)glycine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1C(C(=O)O)N)O)O
• Uses: 2-(3,4-Dihydroxyphenyl)glycine, is a building block.

Technology Process of 2-Amino-2-(3,4-dihydroxyphenyl)acetic acid

There total 4 articles about 2-Amino-2-(3,4-dihydroxyphenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

D-α-amino-m,p-dimethoxyphenylacetic acid (91819-11-3) → DL-2-(3,4-Dihydroxyphenyl)glycin (138-62-5,16534-84-2)

Guidance literature:

With hydrogen bromide; for 3h; Heating;

Reference yield:

amino-(4-hydroxy-3-methoxy-phenyl)-acetic acid (56246-88-9) → DL-2-(3,4-Dihydroxyphenyl)glycin (138-62-5,16534-84-2)

Guidance literature:

With hydrogen iodide;

Reference yield:

vanillin (121-33-5,8014-42-4) → DL-2-(3,4-Dihydroxyphenyl)glycin (138-62-5,16534-84-2)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium chloride; water; diethyl ether / nachfolgend Behandeln mit Salzsaeure

2: hydriodic acid

With diethyl ether; ammonium chloride; water; hydrogen iodide;

upstream raw materials:

amino-(4-hydroxy-3-methoxy-phenyl)-acetic acid

D-α-amino-m,p-dimethoxyphenylacetic acid

vanillin

Refernces

• 1、 -. "Derivatives of 7-(cyclized)phenylglycyl-3-triazolo-thio methyl cephalosporin". . . Retrieved 2008/06/13.