Technology Process of 4-chloro-5-(3-(methylsulfonyl)phenyl)thieno[2,3-d]pyrimidine
There total 5 articles about 4-chloro-5-(3-(methylsulfonyl)phenyl)thieno[2,3-d]pyrimidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); sodium carbonate;
In
1,2-dimethoxyethane; water;
at 120 ℃;
for 0.333333h;
Microwave irradiation;
DOI:10.7554/eLife.29123
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
1.2: 2 h / 0 °C / Inert atmosphere
2.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,2-dimethoxyethane; water / 0.33 h / 120 °C / Microwave irradiation
With
tetrakis(triphenylphosphine) palladium(0); isopropylmagnesium chloride; sodium carbonate;
In
tetrahydrofuran; 1,2-dimethoxyethane; water;
DOI:10.7554/eLife.29123
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
2.2: 0.33 h
3.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 0.33 h / 120 °C / Sealed microwave vial
With
n-butyllithium; isopropylmagnesium chloride; sodium carbonate; diisopropylamine;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; 1,2-dimethoxyethane; water;