1-Methoxyisoquinoline

Base Information

• Chemical Name: 1-Methoxyisoquinoline
• CAS No.: 23724-93-8
• Molecular Formula: C₁₀H₉NO
• Molecular Weight: 159.188
• Mol file: 23724-93-8.mol

Synonyms:1-Methoxyisoquinoline;NSC 158305

Chemical Property of 1-Methoxyisoquinoline

Chemical Property:

• Vapor Pressure: 0.0108mmHg at 25°C
• Boiling Point: 271.3°Cat760mmHg
• PKA: 3.05±0.20(Predicted)
• Flash Point: 99.5°C
• PSA: 22.12000
• Density: 1.13g/cm³
• LogP: 2.24340

Purity/Quality:

99%min ^*data from raw suppliers

1-Methoxyisoquinoline 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Methoxyisoquinoline

There total 11 articles about 1-Methoxyisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-chloroisoquinoline (19493-44-8) + sodium methylate (124-41-4) → 1-Methoxyisochinolin (23724-93-8)

Guidance literature:

In methanol; for 22.5h; Inert atmosphere; Reflux;

DOI:10.1021/acs.orglett.9b01805

Reference yield: 85.0%

5-Methoxy-1,4-benzothiazepin (115483-69-7) → 1-Methoxyisochinolin (23724-93-8)

Guidance literature:

In n-heptane; for 14h; Heating;

Reference yield: 22.0%

1-methoxyisoquinoline 2-oxide (76570-09-7) → 1-Methoxyisochinolin (23724-93-8) + methyl 2-hydroxystyrylcarbamate (76570-13-3)

Guidance literature:

In benzene; at 15 ℃; Irradiation;

upstream raw materials:

1-hydroxyisoquinoline

methyl iodide

1-chloroisoquinoline

sodium methylate

Downstream raw materials:

1-benzoylisoquinoline

N-methylisocarbostyril

α-phenyl-1-isoquinolineacetonitrile

Refernces

• 1、 Paquette et al.. "-". . p. 5522,5526. Retrieved 1969.
• 2、 Shigeno, Masanori,Hayashi, Kazutoshi,Nozawa-Kumada, Kanako,Kondo, Yoshinori. "Organic Superbase t-Bu-P4 Catalyzes Amination of Methoxy(hetero)arenes". supporting information. p. 5505 - 5508. Retrieved 2019/08/01.
• 3、 Hofmann, Hans,Fischer, Herbert. "Heterocyclic Seven-Membered Ring Compounds, XXXIII. - Synthesis and Properties of 5-Methoxy-1,4-benzothiazepine and of 5-Methoxy-1-methyl-1,4-benzothiazepinium Tetrafluoroborate". . p. 2147 - 2150. Retrieved 2007/10/02.