2-ACETYL-5-NITROBENZO[B]FURAN

Base Information

• Chemical Name: 2-ACETYL-5-NITROBENZO[B]FURAN
• CAS No.: 23136-39-2
• Molecular Formula: C10H7NO4
• Molecular Weight: 205.17
• Hs Code.: 2932999099
• Mol file: 23136-39-2.mol

Synonyms:Ketone,methyl 5-nitro-2-benzofuranyl (8CI);2-Acetyl-5-nitrobenzofuran;

Chemical Property of 2-ACETYL-5-NITROBENZO[B]FURAN

Chemical Property:

• Vapor Pressure: 4.5E-05mmHg at 25°C
• Melting Point: 175 °C
• Refractive Index: 1.625
• Boiling Point: 350.1 °C at 760 mmHg
• Flash Point: 165.5 °C
• PSA: 76.03000
• Density: 1.37g/cm³
• LogP: 3.06680

Purity/Quality:

99% ^*data from raw suppliers

2-Acetyl-5-nitrobenzo[b]furan ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-ACETYL-5-NITROBENZO[B]FURAN

There total 10 articles about 2-ACETYL-5-NITROBENZO[B]FURAN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-Nitrosalicylaldehyde (97-51-8) + 1-bromoacetone (598-31-2) → 2-acetyl-5-nitrobenzofuran (23136-39-2)

Guidance literature:

5-Nitrosalicylaldehyde; With potassium hydroxide; In ethanol; for 0.25h; Cooling with ice;

1-bromoacetone; With potassium iodide; In ethanol; Cooling;

Reference yield: 68.0%

(2-hydroxy-5-nitrobenzyl)triphenylphosphine chloride (70726-17-9) + pyruvoyl chloride (5704-66-5) → 2-acetyl-5-nitrobenzofuran (23136-39-2)

Guidance literature:

In xylene; for 0.5h; Heating;

Reference yield: 67.0%

5-Nitrosalicylaldehyde (97-51-8) + acetone (67-64-1) → 2-acetyl-5-nitrobenzofuran (23136-39-2)

Guidance literature:

With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide; In water; at 60 ℃; for 8h;

DOI:10.1016/j.tetlet.2017.11.043

upstream raw materials:

1-(benzo[b]furan-2-yl)ethanone

ethyl (2-chloroaceto)acetate

5-Nitrosalicylaldehyde

(2-hydroxy-5-nitrobenzyl)triphenylphosphine chloride

Refernces

• 1、 Wang, Lei,Wu, Yu-Ran,Ren, Shu-Ting,Yin, Long,Wang, You-Xian,Liu, Shu-Hao,Liu, Wei-Wei,Shi, Da-Hua,Cao, Zhi-Ling,Sun, Hui-Min. "Synthesis and bioactivity of novel C2-glycosyl benzofuranylthiazoles derivatives as acetylcholinesterase inhibitors". . p. 257 - 261. Retrieved 2019/09/03.
• 2、 Santhosh Kumar,Ravikumar,Chinna Ashalu,Rajender Reddy. "TBAI/TBHP mediated oxidative cross coupling of ketones with phenols and carboxylic acids: Direct access to benzofurans". supporting information. p. 33 - 37. Retrieved 2017/12/11.