bis-gamma-glutamylcystine

Base Information

• Chemical Name: bis-gamma-glutamylcystine
• CAS No.: 23052-19-9
• Molecular Formula: C16H26 N4 O10 S2
• Molecular Weight: 498.535
• Metabolomics Workbench ID: 70955
• Nikkaji Number: J1.707.057F
• Mol file: 23052-19-9.mol

Synonyms:Cystine,N,N'-di-L-g-glutamyl-, L- (8CI); Cystine,N,N'-di-g-glutamyl- (7CI); Bis(g-glutamyl)cystine

Chemical Property of bis-gamma-glutamylcystine

Chemical Property:

• Refractive Index: 1.648
• Boiling Point: 968°Cat760mmHg
• Flash Point: 539.2°C
• PSA: 338.02000
• Density: 1.558g/cm³
• LogP: 0.25400
• XLogP3: -7.8
• Hydrogen Bond Donor Count: 8
• Hydrogen Bond Acceptor Count: 14
• Rotatable Bond Count: 17
• Exact Mass: 498.10903539
• Heavy Atom Count: 32
• Complexity: 650

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CC(=O)NC(CSSCC(C(=O)O)NC(=O)CCC(C(=O)O)N)C(=O)O)C(C(=O)O)N
• Isomeric SMILES: C(CC(=O)N[C@@H](CSSC[C@@H](C(=O)O)NC(=O)CC[C@@H](C(=O)O)N)C(=O)O)[C@@H](C(=O)O)N

Technology Process of bis-gamma-glutamylcystine

There total 8 articles about bis-gamma-glutamylcystine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-L-γ-glutamyl-L-cysteine (636-58-8,6710-20-9) → (γEC)2 (23052-19-9,117596-69-7,33514-37-3,62314-66-3,85051-42-9)

Guidance literature:

With dihydrogen peroxide; copper(II) sulfate;

Reference yield:

gamma-glutamylcysteine (6710-20-9) → di-γ-glutamyl-cystine (23052-19-9,117596-69-7,33514-37-3,62314-66-3,85051-42-9)

Guidance literature:

With tris(2-carboxyethyl)phosphine; recombinant ovothiol A from Erwinia tasmaniensis; iron(II) sulfate; sodium chloride; D,L-histidine; at 26 ℃; pH=8; Tris-HCl buffer; Enzymatic reaction;

DOI:10.1021/ja109378e

Reference yield:

N,N'-bis-(N-carbamoyl-γ-glutamyl)-cystine → di-γ-glutamyl-cystine (23052-19-9,117596-69-7,33514-37-3,62314-66-3,85051-42-9)

Guidance literature:

With potassium nitrite; di--l-cystine; Ein teilweise racemisiertes Praeparat;

upstream raw materials:

cystine dimethyl ester

water

gamma-glutamylcysteine

Oxidized glutathione

Downstream raw materials:

N-L-γ-glutamyl-L-cysteine

cysteine disulfide

C₂₁H₂₈BrN₅O₉S₂

Refernces

• 1、 Krezel, Artur,Wojcik, Jacek,Maciejczyk, Maciej,Bal, Wojciech. "Zn(II) complexes of glutathione disulfide: Structural basis of elevated stabilities". experimental part. p. 72 - 85. Retrieved 2011/02/27.