HPOB

Base Information

• Chemical Name: HPOB
• CAS No.: 1429651-50-2
• Molecular Formula: C₁₇H₁₈N₂O₄
• Molecular Weight: 314.341
• Mol file: 1429651-50-2.mol

Synonyms:(4-(hydroxyamino)carbonyl)-N-(2-hydroxyethyl)-N-phenyl-benzeneacetamide

Chemical Property of HPOB

Chemical Property:

• Storage Temp.: 2-8°C
• Solubility.: DMSO: soluble1mg/mL, clear (warmed)

Purity/Quality:

99%+, ^*data from raw suppliers

HPOB ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: HPOB is a histone deacetylase 6 inhibitor used in the enhancement of anti-cancer drugs.

Technology Process of HPOB

There total 7 articles about HPOB which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4-(2-((2-((tert-butyldimethylsilyl)oxy)ethyl)(phenyl)amino)-2-oxoethyl)-N-hydroxybenzamide (1429653-16-6) → (4-(hydroxyamino)carbonyl)-N-(2-hydroxyethyl)-N-phenyl-benzeneacetamide (1429651-50-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

Reference yield:

methyl 4-(2-((2-((tert-butyldimethylsilyl)oxy)ethyl)(phenyl)amino)-2-oxoethyl)benzoate (1429653-12-2) → (4-(hydroxyamino)carbonyl)-N-(2-hydroxyethyl)-N-phenyl-benzeneacetamide (1429651-50-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine; potassium cyanide / water; tetrahydrofuran; methanol / 16 h / 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane

With potassium cyanide; hydroxylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

[4-(methoxycarbonyl)phenyl]acetic acid (22744-12-3) → (4-(hydroxyamino)carbonyl)-N-(2-hydroxyethyl)-N-phenyl-benzeneacetamide (1429651-50-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere

2: hydroxylamine; potassium cyanide / water; tetrahydrofuran; methanol / 16 h / 20 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane

With potassium cyanide; hydroxylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water;

upstream raw materials:

methyl 4-(2-((2-((tert-butyldimethylsilyl)oxy)ethyl)(phenyl)amino)-2-oxoethyl)benzoate

[4-(methoxycarbonyl)phenyl]acetic acid

4-(2-((2-((tert-butyldimethylsilyl)oxy)ethyl)(phenyl)amino)-2-oxoethyl)-N-hydroxybenzamide

4-hydroxymethylphenylacetic acid

Refernces