3',5'-dibromofolic acid

Base Information

• Chemical Name: 3',5'-dibromofolic acid
• CAS No.: 2536-53-0
• Molecular Formula: C₁₉H₁₇Br₂N₇O₆
• Molecular Weight: 599.195
• Mol file: 2536-53-0.mol

Synonyms:Glutamicacid, N-[4-[[(2-amino-4-hydroxy-6-pteridinyl)methyl]amino]-3,5-dibromobenzoyl]-(7CI); Glutamic acid,N-[4-[[(2-amino-4-hydroxy-6-pteridinyl)methyl]amino]-3,5-dibromobenzoyl]-, L-(8CI)

Chemical Property of 3',5'-dibromofolic acid

Chemical Property:

• PSA: 217.76000
• LogP: 2.47040
• Storage Temp.: ?20°C

Purity/Quality:

98% ^*data from raw suppliers

3,5-DibromofolicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,5-Dibromofolic acid is used in modified preparation of folic acid labeled with 2H at the 3'',?5''-?positions for use in in vivo studies of folate absorption, metab., and turnover.

Technology Process of 3',5'-dibromofolic acid

There total 2 articles about 3',5'-dibromofolic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Folic acid → N-(3',5'-dibromo-pteroyl)-L-glutamic acid (2536-53-0)

Guidance literature:

With bromine;

DOI:10.1021/ja01150a041

Reference yield:

1,1,3-tribromoacetone (3475-39-6) + N-(4-amino-3,5-dibromo-benzoyl)-L-glutamic acid (884312-24-7) → N-(3',5'-dibromo-pteroyl)-L-glutamic acid (2536-53-0)

Guidance literature:

DOI:10.1021/ja01150a041

Reference yield:

N-(3',5'-dibromo-pteroyl)-L-glutamic acid (2536-53-0) → N-(3',5'-dibromo-10-nitroso-pteroyl)-L-glutamic acid

Guidance literature:

With hydrogenchloride; sodium nitrite;

DOI:10.1021/ja01150a041

upstream raw materials:

1,1,3-tribromoacetone

N-(4-amino-3,5-dibromo-benzoyl)-L-glutamic acid