PIPERIDIN-1-YLMETHANOL

Base Information

• Chemical Name: PIPERIDIN-1-YLMETHANOL
• CAS No.: 2494-10-2
• Molecular Formula: C6H13 N O
• Molecular Weight: 115.175
• Mol file: 2494-10-2.mol

Synonyms:1-(Hydroxymethyl)piperidine;N-(Hydroxymethyl)piperidine; N-Methylolpiperidine

Chemical Property of PIPERIDIN-1-YLMETHANOL

Chemical Property:

• PSA: 23.47000
• LogP: 0.36000

Purity/Quality:

PIPERIDIN-1-YL-METHANOL 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PIPERIDIN-1-YLMETHANOL

There total 2 articles about PIPERIDIN-1-YLMETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperidine (110-89-4) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → 1-piperidinomethanol (2494-10-2) + di(N-piperidinyl)methane (880-09-1)

Guidance literature:

at 20 - 65 ℃; for 13h;

DOI:10.1002/poc.3958

Reference yield:

piperidine (110-89-4) → 1-piperidinomethanol (2494-10-2) + N-Formylpiperidine (2591-86-8) + piperidin-1-yl-acetonitrile (3010-03-5)

Guidance literature:

With sodium hydroxide; In water; at 70 ℃; for 5h; Yields of byproduct given;

DOI:10.1007/BF00956799

Reference yield: 50.0%

1-piperidinomethanol (2494-10-2) → piperidine (110-89-4) + di(N-piperidinyl)methane (880-09-1) + formaldehyd (50-00-0,30525-89-4,61233-19-0)

Guidance literature:

palladium(II) acetylacetonate; triethylaluminum; triphenylphosphine; In toluene; at 100 ℃; for 4h;

DOI:10.1007/BF00961758

upstream raw materials:

piperidine

formaldehyd

Downstream raw materials:

di(N-piperidinyl)methane

1,3-bis-piperidin-1-ylmethyl-imidazolidine-2-thione

1-[(1-methyl-1-phenyl-ethyl)-peroxymethyl]-piperidine

1-phenyl-3-piperidino-propane-1,2-dione-2-oxime

Refernces

• 1、 Troyanskii, E. I.,Ioffe, V. A.,Nikishin, G. I.. "OXIDATION OF AZACYCLOALKANES". . p. 2351 - 2359. Retrieved 2007/10/02.