METHYL 3-METHOXY-4,5-METHYLENEDIOXYBENZOATE

Base Information

• Chemical Name: METHYL 3-METHOXY-4,5-METHYLENEDIOXYBENZOATE
• CAS No.: 22934-58-3
• Molecular Formula: C10H10 O5
• Molecular Weight: 210.186
• Mol file: 22934-58-3.mol

Synonyms:Benzoicacid, 3-methoxy-4,5-(methylenedioxy)-, methyl ester (6CI,8CI);3-Methoxy-4,5-methylenedioxybenzoic acid methyl ester; Methyl3,4-methylenedioxy-5-methoxybenzoate; Methyl3-methoxy-4,5-(methylenedioxy)benzoate; Myristicin acid methyl ester

Chemical Property of METHYL 3-METHOXY-4,5-METHYLENEDIOXYBENZOATE

Chemical Property:

• Melting Point: 91℃
• PSA: 53.99000
• LogP: 1.21050

Purity/Quality:

98%min ^*data from raw suppliers

MyristicinAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 3-METHOXY-4,5-METHYLENEDIOXYBENZOATE

There total 25 articles about METHYL 3-METHOXY-4,5-METHYLENEDIOXYBENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl 3,4-dihydroxy-5-methoxybenzoate (3934-86-9) + 1,1-dibromomethane (74-95-3) → methyl 7-methoxybenzo[d][1,3]dioxole-5-carboxylate (22934-58-3)

Guidance literature:

With cesium fluoride; In N,N-dimethyl-formamide; for 2h; Heating;

DOI:10.1139/v87-399

Reference yield: 97.0%

methyl 3,4-dihydroxy-5-methoxybenzoate (3934-86-9) → methyl 7-methoxybenzo[d][1,3]dioxole-5-carboxylate (22934-58-3)

Guidance literature:

With potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; at 105 ℃; for 6h;

DOI:10.1016/j.bmcl.2008.08.050

Reference yield: 92.0%

diiodomethane (75-11-6) + methyl 3,4-dihydroxy-5-methoxybenzoate (3934-86-9) → methyl 7-methoxybenzo[d][1,3]dioxole-5-carboxylate (22934-58-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1039/d2ra00499b

upstream raw materials:

diazomethane

5-methoxy-3,4-methylenedioxybenzoic acid

methanol

methyl 3,4-dihydroxy-5-methoxybenzoate

Downstream raw materials:

4-bromo-7-methoxybenzo[1,3]dioxole-5-carboxylic acid methyl ester

3-(3-hydroxy-4-methoxyphenyl)-5-(3-methoxy-4,5-methylenedioxyphenyl)-1,2,4-triazole

C₁₇H₁₆N₂O₇

C₁₉H₂₀N₂O₈

Refernces

• 1、 Karasawa, Daichi,Nishii, Yoshinori,Oshima, Mizuki,Ota, Ryotaro,Shimasaki, Noriko,Watashi, Koichi. "Asymmetric total synthesis of four bioactive lignans using donor-acceptor cyclopropanes and bioassay of (?)- and (+)-niranthin against hepatitis B and influenza viruses". . p. 4635 - 4639. Retrieved 2022/02/19.
• 2、 Wang, Qinghui,Arnst, Kinsie E.,Wang, Yuxi,Kumar, Gyanendra,Ma, Dejian,Chen, Hao,Wu, Zhongzhi,Yang, Jinliang,White, Stephen W.,Miller, Duane D.,Li, Wei. "Structural Modification of the 3,4,5-Trimethoxyphenyl Moiety in the Tubulin Inhibitor VERU-111 Leads to Improved Antiproliferative Activities". . p. 7877 - 7891. Retrieved 2018/09/12.