DL-3-ACETOXYBUTYRIC ACID ETHYL ESTER

Base Information

• Chemical Name: DL-3-ACETOXYBUTYRIC ACID ETHYL ESTER
• CAS No.: 27846-49-7
• Molecular Formula: C8H14O4
• Molecular Weight: 174.197
• Hs Code.: 2918990090
• Mol file: 27846-49-7.mol

Synonyms:Acetoxybutyricacidethylester;Ethyl 3-(acetyloxy)butanoate;Ethyl (±)-3-acetoxybutyrate;Ethyl 3-acetoxybutanoate;

Chemical Property of DL-3-ACETOXYBUTYRIC ACID ETHYL ESTER

Chemical Property:

• Refractive Index: 1.4140-1.4170
• Boiling Point: 155.6 °C at 760 mmHg
• Flash Point: 60.3 °C
• PSA: 52.60000
• Density: 1.037 g/cm³
• LogP: 0.89120

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl3-Acetyloxybutanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DL-3-ACETOXYBUTYRIC ACID ETHYL ESTER

There total 8 articles about DL-3-ACETOXYBUTYRIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl-β-acetoxycrotonate (27750-19-2) → ethyl 3-acetoxybutanoate (27846-49-7)

Guidance literature:

With hydrogen; Rh on carbon; In tetrahydrofuran; under 735.5 Torr; Ambient temperature;

DOI:10.1016/S0040-4039(00)86736-2

Reference yield: 100.0%

ethyl 3-hydroxybutyrate (5405-41-4) + acetic anhydride (108-24-7) → ethyl 3-acetoxybutanoate (27846-49-7)

Guidance literature:

With pyridine; at 20 ℃; for 48h;

DOI:10.1002/chem.200304761

Reference yield: 100.0%

3-acetoxy-crotonic acid ethyl ester (29214-62-8) → ethyl 3-acetoxybutanoate (27846-49-7)

Guidance literature:

With hydrogen; Rh on carbon; under 760 Torr; Ambient temperature;

DOI:10.1016/S0040-4039(00)86736-2

upstream raw materials:

aluminum ethoxide

acetaldehyde

ethyl 3-hydroxybutyrate

acetyl chloride

Downstream raw materials:

2-butenoic acid

Refernces

• 1、 Lillo, Vanesa,Geier, Michael J.,Westcott, Stephen A.,Fernandez, Elena. "Ni and Pd mediate asymmetric organoboron synthesis with ester functionality at the β-position". supporting information; experimental part. p. 4674 - 4676. Retrieved 2009/12/08.
• 2、 Rozzell, J. David. "PREPARATION OF DIASTEREOISOMERIC 2-DEUTERIO-3-HYDROXY BUTYRATE. A GENERAL METHOD FOR HYDROGENATION OF β-ACYLOXY-α,β-UNSATURATED CROTONATES". . p. 1767 - 1770. Retrieved 2007/10/02.