3H-Indol-3-one, 2-(p-bromophenyl)-, 1-oxide

Base Information

• Chemical Name: 3H-Indol-3-one, 2-(p-bromophenyl)-, 1-oxide
• CAS No.: 27820-27-5
• Molecular Formula: C14H8 Br N O2
• Molecular Weight: 302.12
• Mol file: 27820-27-5.mol

Synonyms:3H-Indol-3-one,2-(p-bromophenyl)-, 1-oxide (8CI); NSC 626112

Chemical Property of 3H-Indol-3-one, 2-(p-bromophenyl)-, 1-oxide

Chemical Property:

• Boiling Point: 468.8±47.0 °C(Predicted)
• PKA: -1.93±0.20(Predicted)
• PSA: 45.82000
• Density: 1.65±0.1 g/cm3(Predicted)
• LogP: 3.23530

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3H-Indol-3-one, 2-(p-bromophenyl)-, 1-oxide

There total 3 articles about 3H-Indol-3-one, 2-(p-bromophenyl)-, 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-1-ethynylbenzene (766-96-1) + o-nitroiodobenzene (609-73-4) → 2-(4-bromo-phenyl)-indol-3-one-1-oxide (27820-27-5)

Guidance literature:

4-bromo-1-ethynylbenzene; o-nitroiodobenzene; With triethylamine; at 20 ℃; for 0.5h; Inert atmosphere;

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; at 20 ℃; for 12h; Inert atmosphere;

With acetic acid; In acetonitrile; at 45 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c9cc05719f

Reference yield:

1-(4-bromo-α'-hydroxy-2'-nitro-bibenzyl-α-yl)-pyridinium; bromide → 2-(4-bromo-phenyl)-indol-3-one-1-oxide (27820-27-5)

Guidance literature:

With acetic acid; Irradiation_.mit Sonnenlicht oder mit UV-Licht;

Reference yield:

1-(4-bromo-benzyl)-pyridinium (89047-29-0) → 2-(4-bromo-phenyl)-indol-3-one-1-oxide (27820-27-5)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol; methanol; aq.-ethanolic NaOH-solution

2: aqueous acetic acid / Irradiation_.mit Sonnenlicht oder mit UV-Licht

With methanol; sodium hydroxide; ethanol; acetic acid;

upstream raw materials:

1-(4-bromo-benzyl)-pyridinium

4-bromo-1-ethynylbenzene

o-nitroiodobenzene

Refernces